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Comparison of cell adhesion properties using different binding materials for cell-based bio-transistors applications

文献类型： 会议论文

第一作者： Xinyue Liu

作者： Xinyue Liu 1 ; Miyuki Tabata 1 ; Yuji Miyahara 1 ;

作者机构： 1.Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

关键词： ISFET pH sensor;Breast cancer cells;Liquid biopsy

会议名称： センサ・マイクロマシンと応用システム シンポジウム

主办单位：

页码： 55-57

摘要： Nowadays, biosensors are portable devices and sensitive detections with fast response, which play an important role in early disease diagnosis. Ion-sensitive field effect transistor (ISFET) is one of the pH sensors having advantages such as small size, simple operation and high sensitivity. In this study, we tried to evaluate the cell adhesion properties on a gate surface of the ISFET by varying different binding materials (bare gate surface, poly-L-lysine, ECM-gel and fibronectin human plasma). The results of pH sensitivity measurement and microscope observation, the cells were maintained on ECM-gel even after the pH monitoring process and cells showed the excellent cell adhesion property on ECM-gel pre-treatment surface compared with the other materials.

分类号： TP212-53

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[1]The study of chemical functionalization on tantalum oxide surface utilized for ISFET pH sensor in biomedical field. Chattarika Khamhanglit,Miyuki Tabata,Yuji Miyahara. 2020

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