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Electrochemical label-free degranulation monitoring for in-situ evaluation of cellular function

文献类型： 会议论文

第一作者： Miyuki Tabata

作者： Miyuki Tabata 1 ; Tatsuro Goda 1 ; Akira Matsumoto 1 ; Yuji Miyahara 1 ;

作者机构： 1.the Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

关键词： RBL-2H3;ISFET;in-situ evaluation

会议名称： Annual International Conference of the IEEE Engineering in Medicine and Biology Society

主办单位：

页码： 3177-3180

摘要： We fabricated a degranulation monitoring device, combining ion-sensitive field-effect transistor (ISFET) and microperfusion system. The electrical properties of ISFET were maintained even after immobilization of RBL-2H3 mast cells on the sensor. We successfully demonstrated in-situ monitoring of degranulation from stimulated RBL-2H3 cells by ionomycin. Potential change was induced by the release of acid-granule contents, which result in local pH decrease on the sensor under physiological conditions. This microdevice is expected to contribute as a platform technology for evaluating induced immune responses by chemical compounds.

分类号： Q81-53

  • 相关文献

[1]Electrochemical label-free degranulation monitoring for in-situ evaluation of cellular function. Tabata, Miyuki,Goda, Tatsuro,Matsumoto, Akira,Miyahara, Yuji. 2015

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