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Control Of Protein Initial Burst From Zinc-Hydroxyapatite / Poly(L-Lactide) System

文献类型: 会议论文

第一作者: Toru Tonegawa

作者: Toru Tonegawa 1 ; Toshiyuki Ikoma 2 ; Guoping Chen 3 ; Junzo Tanaka;

作者机构: 1.Graduate School of Pure and Applied Sciences, University of Tsukuba, Ibaraki, Japan

2.National Institute for Materials Science, Biomaterials Center, Ibaraki, Japan

3.Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, Tokyo, Jap

关键词: hydroxyapatite;nanocrystal;zinc ion;spray drying method;drug delivery system;poly (L-Lactide) coating;sustained release

会议名称: Bioceramics vol.19 pt.2

主办单位:

页码: 855,860-

摘要: Control of protein release without the initial burst from zinc containing hydroxyapatite porous microparticles (Zn-HAp) was investigated with a novel formulation method. The formulation method was a coat of polyL(L-lactide; PLA) on the microparticle with nano-thickness, which obviously suppressed the initial burst of protein release compared with the microparticles without the formulation, the coat of PLA. The HAp/PLA microparticle with l-20μm of the size distribution was available for the drug delivery carrier of proteins without the degradation.

分类号: [ "R318.08" , "R318.08"]

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