Novel Local Treatment with Paclitaxel-loaded Hydroxyapatite-alginate Gels for Spinal Bone Metastases
文献类型: 会议论文
第一作者: Tetsuya Abe
作者: Tetsuya Abe 1 ; Masataka Sakane 2 ; Toshiyuki lkoma; Toru Tonegawa; Tomonori Yoshioka; Junzo Tanaka; Naoyuki Ochiai;
作者机构: 1.Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
2.Biomaterials Center, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki 30
关键词: local treatment;bone metastases;paclitaxel;hydroxyapatite;animal model
会议名称: Bioceramics vol.19 pt.2
主办单位:
页码: 1343,1346-
摘要: The extent of osseous involvement, particularly spinal cord compression, is directly correlated with patient survival. To treat metastatic spine cancer, we have developed novel paclitaxel-loaded hydroxyapatite-alginate gels. In this study, an intraosseous spinal cancer model in rats was used to investigate the efficacy of local treatment. Ten rats were randomized into two groups, a local treatment group and a control group. Disease-free time and survival rate in the local treatment group were significantly longer in this model. (p < 0.05)
分类号: [ "R318.08" , "R318.08"]
- 相关文献
[1]Ultrasonic Assisted Extraction of Paclitaxel from Taxus x media Using Ionic Liquids as Adjuvants: Optimization of the Process by Response Surface Methodology. Tan, Zhijian,Wang, Chaoyun,Zhou, Wanlai,Yang, Yuanru,Wang, Hongying,Yi, Yongjian,Tan, Zhijian,Wang, Chaoyun,Zhou, Wanlai,Yang, Yuanru,Wang, Hongying,Yi, Yongjian,Li, Qiao,Li, Fenfang.
[2]VERTEBRAL TRABECULAR TISSUE MODULUS OF GOAT AS COMPARED TO HUMAN USING ULTRASONIC AND MICROCT APPROACH. Jeremy CM Teo,Andy ZC Png,Swee Hin Teoh. 2004
[3]Repairing Segmental Defect with a Composite Associating Collagen Membrane and MBCP~R Combined with Total Bone Marrow Graft in Irradiated Bone Defect: an Experimental Study in Rabbit. F. Jegoux,E. Aguado,R. Cognet,O. Malard,F. Moreau,G. Daculsi,E. Goyenvalle. 2008
[4]Neuronal plasticity of trigeminal ganglia in mice following nerve injury. Lynds, Randi,Shi, Xie-Qi,Lynds, Randi,Shi, Xie-Qi,Lyu, Chuang,Lyu, Gong-Wei,Rosen, Annika,Rosen, Annika,Mustafa, Kamal,Shi, Tie-Jun Sten. 2017
[5]Transiently impaired neurogenesis in MPTP mouse model of Parkinson's disease. He, Xi Jun,He, Xi Jun,Nakayama, Hiroyuki.
[6]Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway in Vitro and in a Rodent Model. Ji, Hongchen,Li, Xiao,Yue, Shuqiang,Zhang, Zhuochao,Ma, Ben,Wang, Jing,Pu, Meng,Wang, Desheng,Duan, Juanli,Tao, Kaishan,Dou, Kefeng,Li, Junjie,Chen, Hui,Zhou, Liang,Feng, Chong,Pan, Dengke. 2015
[7]Estimation of Genetic Parameters for Growth Traits in a Crossbred Population Derived from Piedmontese and Nanyang Cattle Using a Multi-Trait Animal Model. Zhu, H. B.,Wang, D.,Hao, H. S.,Du, W. H.,Zhao, X. M.,Chen, J.,Wang, F. Q.. 2012
[8]Regulation of organic nucleic acids and serum biochemistry parameters by dietary chromium picolinate supplementation in swine model. Yang Jiajun,Han Aiyun,Zheng Shanshan,Zhang Minhong. 2011
[9]CRISPR/Cas9-mediated ApoE(-/-) and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels. Huang, Lei,Cheng, Ying,Xu, Kui,Gao, Qian,Xia, Ying,Liu, Yang,Zhang, Xue,Mu, Yulian,Li, Kui,Hua, Zaidong,Xiao, Hongwei,Zheng, Xinming,Huang, Lei. 2017
[10]Passive immunotherapy for Middle East Respiratory Syndrome coronavirus infection with equine immunoglobulin or immunoglobulin fragments in a mouse model. Zhao, Yongkun,Wang, Chong,Qiu, Boning,Wang, Hualei,Jin, Hongli,Gai, Weiwei,Zheng, Xuexing,Wang, Tiecheng,Sun, Weiyang,Yan, Feihu,Gao, Yuwei,Yang, Songtao,Xia, Xianzhu,Wang, Chong,Qiu, Boning,Gai, Weiwei,Penman, Stanley,Li, Chufang,Wang, Qian,Chen, Ling,Zhong, Nanshan,Zhao, Jincun,Zhao, Yongkun,Wang, Hualei,Wang, Tiecheng,Sun, Weiyang,Gao, Yuwei,Yang, Songtao,Xia, Xianzhu,Yan, Jinghua.
[11]Corrosion Resistance Study of Electrophoretic Deposited Hydroxyapatite on Stainless Steel for Implant Applications. Kean-Khoon Chew,Sharif Hussein Sharif Zein,Abdul Latif Ahmad,David S. McPhail,Aldo R. Boccaccini. 2012
[12]Ultrastructural Characteristics of Tissue Response after Implantation of Calcium Phosphate Ceramics in the Mandible of Rabbit. V. Zalite,V. Groma,D. Jakovlevs,J. Locs,G. Salms. 2013
[13]Manufacturing and characterization of hydroxyapatite foams produced by gel-casting technique. Gonzalez, J.I.,Escobar, D.M.,Ossa, C.P.O.. 2013
[14]Bone Regeneration Materials. Masanori Kikuchi,Junzo Tanaka. 2007
[15]Preparation of a Bioactive Xenograft. Hyung-Sup Kim,Yong-Keun Lee,Bum-Soon Lim,Chong-Pyong Chung,Sang-Hoon Rhee. 2007
[16]Development of Poly(vinyl alcohol)-Collagen-Hydroxyapatite Nanohybrids for Tissue Grafting. Xiaomin Wang,Xudong Li,Guiqiu Zheng,Xiaoliang Wang,Xingdong Zhang,Zhongwei Gu. 2007
[17]Parameters Influencing the Properties of Calcium Phosphate Cements. Lydia Heimann,Stefan Deusser,Elvira Dingeldein. 2008
[18]Adsorption and Effectiveness of Different Antibiotics on Pure Hydroxyapatite (HA) with Controlled Porosity. F. Chai,J.-C. Hornez,N. Blanchemain,C. Neut,M. Descamps,H. F. Hildebrand. 2007
[19]Osteointegration of HA-Coated Subperiosteal Dental Implants: Preliminary Work. M.C. Ibanez,C. Bourgeois,J.E. Lemons. 2009
[20]Antibacterial activity of Silver-Hydroxyapatite/ Titania Nanocomposite Coating on Titanium against Oral Bacteria. Anchun Mo,Wei Xu,Suqin Xian,Yubao Li,Shi Bai. 2007
作者其他论文 更多>>
-
Bone Regeneration Materials
作者:Masanori Kikuchi;Junzo Tanaka
关键词:tricalcium phosphate;biodegradable polymer;guided bone regeneration;hydroxyapatite;collagen;nanocomposite;bone remodeling process
-
Control Of Protein Initial Burst From Zinc-Hydroxyapatite / Poly(L-Lactide) System
作者:Toru Tonegawa;Toshiyuki Ikoma;Guoping Chen;Junzo Tanaka
关键词:hydroxyapatite;nanocrystal;zinc ion;spray drying method;drug delivery system;poly (L-Lactide) coating;sustained release
-
A Novel Collagen Sponge for Cartilage Tissue Engineering
作者:Guoping Chen;Daisuke Akahane;Naoki Kawazoe;Yoshio Shirasaki;Junzo Tanaka;Katsuyuki Yamamoto;Tateishi Tateishi
关键词:scaffold;collagen sponge;tissue engineering;differentiation;MSC;chondrocyte
-
Gene Expression Profile of Osteoblast-Like Cells on Calcium Phosphate Biomaterials
作者:Taro Takemura;Hongsong Fan;Toshiyuki lkoma;Junzo Tanaka;Nobutaka Hanagata
关键词:hydroxyapatite;tricalcium phosphate;biphasic calcium phosphate;osteoblast;gene expression;DNA microarray
-
Cell Repopulation in Calcium Phosphate Hybridized Tendon Graft
作者:Hirotaka Mutsuzaki;Masataka Sakane;Yumi Katayoshi;Sinya Hattori;Hiromi Nakajima;Junzo Tanaka;Naoyuki Ochiai
关键词:calcium phosphate hybridization;rabbit;cell repopulation;alternate soaking process;anterior cruciate ligament
-
Effect of Surface Electrostatic Property on Chondrogenic Differentiation of Human Mesenchymal Stem Cells
作者:Likun Guo;Yujiang Fan;Naoki Kawazoe;Guoping Chen;Junzo Tanaka;Tetsuya Tateishi;Xingdong Zhang
关键词:surface modification;chondrogenic differentiation;electrostatic property
-
Fabrication and Characterization of Apatite Sintered Bodies with c-Axis Orientation
作者:Kazushi Ohta;Masanori Kikuchi;Junzo Tanaka
关键词:hydroxyapatite;sintered body;crystal orientation


