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Hydroxyapatite/Chondoroitin Sulfate Microparticles as Time-Controlled Release Carrier of Proteins

文献类型: 会议论文

第一作者: H. Watanabe

作者: H. Watanabe 1 ; T. Ikoma 2 ; G. Chen 3 ; J. Tanaka;

作者机构: 1.Graduate School of Pure and Applied Sciences University of Tsukuba, Japan

2.National Institute for Materials Science, Biomaterials Center, Japan

3.Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, Japan

关键词: hydroxyapatite;chondroitin sulfate;composite;microparticle;protein;zinc;sustained release

会议名称: Bioceramics vol.19 pt.2

主办单位:

页码: 1007,1012-

摘要: Time-controlled releases of proteins from hydroxyapatite/chondroitin sulfate (HAp/ChS) spherical microparticles were achieved by the addition of zinc cation into the mixture solutions of HAp/ChS and protein as a novel formulation. The initial bursts of proteins, such as cytochrome c and bovine serum albumin, were apparently suppressed by the amount of zinc cation, which could be attributed to the formation of coordinate bonds of zinc cation among proteins and/or ChS moleculars. The increase of molecular lengths of ChS chains decreased the adsorbed amount of proteins, which did not apparently affected to the release of proteins.

分类号: [ "R318.08" , "R318.08"]

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