文献类型： 会议论文
第一作者： T. Yoshioka
作者： T. Yoshioka 1 ; T. lkoma 2 ; A. Monkawa 3 ; T. Tonegawa; D. Chakarov; B. Kasemo; N. Hanagata; J. Tanaka;
作者机构： 1.Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1, Ookayama, Meguro-ku, Tokyo 152-8550, Japan
2.Biomaterials Center, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan
3.Department of
关键词： hydroxyapatite (HAp);nanocrystal;protein adsorption;QCM-D
会议名称： International Symposium on Ceramics in Medicine;International Society for Ceramics Annual Meeting; 20071024-26;20071024-26; Nantes(FR);Nantes(FR)
主办单位：
页码： 1119,1122-
摘要： Real time adsorption behaviors of six proteins with different isoelectric points on hydroxyapatite (HAp) nanocrystal surfaces have been investigated by using HAp sensors for quartz crystal microbalance with dissipation technique (QCM-D). The dissipation (D)-frequency (f) plots clearly showed that the different types of protein adsorption behaviors; the D-f plots of acidic proteins lie on one straight line with a constant slope under all initial protein concentrations, while those of neutral and basic proteins lie on two straight lines with different slopes. The acidic proteins formed a monolayer, while the neutral and basic proteins could cause conformational changes with the adsorbed amount of proteins. The QCM-D technique with novel HAp nanocrystal sensor is useful for the liquid phase changes of proteins on the surface.
分类号： [ "R318.08" , "R318.08"]
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Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel
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