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Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel

文献类型： 会议论文

第一作者： T. Ikoma

作者： T. Ikoma 1 ; T. Yoshioka 2 ; S. Nakamura 3 ; N. Hanagata; T. Abe; M. Sakane; N. Ochiai; J. Tanaka;

作者机构： 1.Biomaterials Center, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan

2.Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1, Ookayama, Meguro-ku, Tokyo 152-8550, Japan

3.Practical App

关键词： hydroxyapatite (HAp);sodium alginate;paclitaxel (Taxol);barium;spray-dry;DDS

会议名称： International Symposium on Ceramics in Medicine;International Society for Ceramics Annual Meeting; 20071024-26;20071024-26; Nantes(FR);Nantes(FR)

主办单位：

页码： 535,538-

摘要： Rigid hydroxyapatite (HAp)-alginate beads were prepared as drug delivery carriers for an anti-cancer drug, paclitaxel (Taxol). Paclitaxel was loaded into the HAp microparticle in process of a spray-drying technique. The HAp-alginate beads including paclitaxel were obtained by a droplet method into barium solution as ionic cross-linkage and dehydration. Cross-sectional analyses indicated the homogeneity of HAp microparticles and barium ions inside the bead. The ratio of alginate to HAp in the beads dominated both mechanical and swelling properties. Drug-release experiment demonstrated the sustained release of paclitaxel from the beads cross-linked with barium ion for 7 days.

分类号： [ "R318.08" , "R318.08"]

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