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Development of Biocompatible Glue for Minimum Invasive Therapy

文献类型： 会议论文

第一作者： T. Taguchi

作者： T. Taguchi 1 ; H. Saito 2 ; M. Iwasashi 3 ; M. Sakane; S. Kakinoki; N. Ochiai; T. Tateishi;

作者机构： 1.Biomaterials Center, NIMS, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan

2.Furuuchi Chemical Corporation, 6-17-17 Minamiooi, Tokyo 140-0013, Japan

3.University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan

关键词： human serum albumin;glue;citric acid;N-hyroxysuccinimide;crosslink

会议名称： Bioceramics vol.19 pt.2

主办单位：

页码： 1339,1342-

摘要： A biocompatible glue consisting of human serum albumin (HSA) and citric acid derivative (CAD), named CAD-A glue was developed. CAD was successfully synthesized by the reaction between citric acid and N-hydroxysuccinimide in the presence of l-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride. When the CAD-A glue was applied to the collagen-based casings, it took 7 min to obtain half of maximum bonding strength (760 g/cm2). The bonding strength of this glue to collagen-based casings increased with increasing of HSA concentration.The bonding strength of CAD-A glue increased with increasing CAD concentration up to 200 mM, and then decreased with increasing CAD concentration under the fixed HSA concentration (50 w/w%). The CAD-A glue showed excellent wound closure ability rather than fibrin glue when applied to the mouse skin. These results suggested that this developed glue had both tissue compatibility and bonding strength for use in clinical field.

分类号： [ "R318.08" , "R318.08"]

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