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PREPARATION OF HYDROXYAPATITE-ALGINATE GELS AS A CARRIER FOR CONTROLLED RELEASE OF PACLITAXEL

文献类型： 会议论文

第一作者： T. Yoshioka

作者： T. Yoshioka 1 ; T. lkoma 2 ; A. Monkawa 3 ; S. Yunoki; T. Abe; M. Sakane; J. Tanaka;

作者机构： 1.Biomaterials Center, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan

2.Department of Orthopaedic Surgery, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan

3.Department of Metallurgy and Ceram

关键词： hydroxyapatite (HAp);sodium alginate;paclitaxel (taxol);anti-cancer drug;spray-dry;drug delivery system (DDS)

会议名称： Bioceramics vol.19 pt.2

主办单位：

页码： 1053,1056-

摘要： Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 urn in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca~(2+)-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.

分类号： [ "R318.08" , "R318.08"]

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[1]Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel. T. Ikoma,T. Yoshioka,S. Nakamura,N. Hanagata,T. Abe,M. Sakane,N. Ochiai,J. Tanaka. 2008

[2]In vitro regeneration protocol for synthetic seed production in upland cotton (Gossypium hirsutum L.). Genhai Hu,Na Dong,Yan Zhou,Wuwei Ye,Shuxun Yu.

[3]Recyclable magnetic carboxymethyl chitosan/calcium alginate - cellulase bioconjugates for corn stalk hydrolysis. Jiang, Jianfang,Zhao, Jiaqi,He, Chunyang,Cui, Baodong,Xiong, Jun,Ao, Juan,Xiang, Guangyan,Jiang, Hao.

[4]Protein Adsorption on Hydroxyapatite Nano-crystals with Quartz Crystal Microbalance Technique. T. Yoshioka,T. lkoma,A. Monkawa,T. Tonegawa,D. Chakarov,B. Kasemo,N. Hanagata,J. Tanaka. 2008

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