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Porous Body Preparation of Hydroxyapatite/Collagen Nanocomposites for Bone Tissue Regeneration

文献类型： 会议论文

第一作者： M. Kikuchi

作者： M. Kikuchi 1 ; T. Ikoma; D. Syoji; H.N. Matsumoto;

作者机构： 1.Biomaterials Center, National institute for Materials Science, 1-1, Namiki, Tsukuba, Ibaraki 305- 0044, Japan, KIKUCHI.Masanori@nims.go.jp, IKOMA.Toshiyuki@nims.go.jp, TANAKA.Junzo@nims.go.jp

关键词： Porous body;hydroxyapatite/collagen nanocomposite;bone tissue regeneration;elastic property

会议名称： Bioceramics : Proceedings of the ... International Symposium on Ceramics in Medicine : The annual meeting of the international society for ceramics in medicine.

主办单位：

页码： 561-564

摘要： Elastic porous bodies were fabricated from the self-organized hydroxyapatite/collagen nanocomposite fibers by lyophilization with the use of collagen as a binder. The porous bodies obtained rapidly absorbed water droplet on them and composed of interconnected pores. The pore size was depending on freezing temperatures. The porous bodies demonstrated sponge-like elastic property when wetted and 70 kPa in tensile strength. The cell attachment and resorption with osteoclastic cells for the porous bodies examined by animal tests were the same as those for the compact bodies of hydroxyapatite/collagen nanocomposite. These mechanical and biological properties provide easier handling to operator and better cell invasiveness in both in vitro and/n vivo than those of "hard" porous ceramics and "soft" collagen sponges.

分类号： R318.08

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[1]Manufacturing and characterization of hydroxyapatite foams produced by gel-casting technique. Gonzalez, J.I.,Escobar, D.M.,Ossa, C.P.O.. 2013

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