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Electro Fluido Dynamic Techniques To Design Instructive Biomaterials For Tissue Engineering and Drug Delivery

文献类型： 会议论文

第一作者： Vincenzo Guarino

作者： Vincenzo Guarino 1 ; Rosaria Altobelli 1 ; Valentina Cirillo 1 ; Luigi Ambrosio 1 ;

作者机构： 1.Institute for Polymers, Composites and Biomaterials, Department of Chemical Sciences & Materials Technology, National Research Council of Italy, V.le Kennedy 54, Naples, Italy

关键词： physical;biological;fundamental cell-biomaterial

会议名称： International Conference GT70

主办单位：

页码： 020004-1-020004-5

摘要： A large variety of processes and tools is continuously investigated to discover new solutions to design instructive materials with controlled chemical, physical and biological properties for tissue engineering and drug delivery. Among them, electro fluido dynamic techniques (EFDTs) are emerging as an interesting strategy, based on highly flexible and low-cost processes, to revisit old biomaterial's manufacturing approach by utilizing electrostatic forces as the driving force for the fabrication of 3D architectures with controlled physical and chemical functionalities to guide in vitro and in vivo cell activities. By a rational selection of polymer solution properties and process conditions, EFDTs allow to produce fibres and/or particles at micro and/or nanometric size scale which may be variously assembled by tailored experimental setups, thus giving the chance to generate a plethora of different 3D devices able to incorporate biopolymers (i.e., proteins, polysaccharides) or active molecules (e.g., drugs) for different applications. Here, we focus on the optimization of basic EFDTs - namely electrospinning, electro spraying and electrodynamic atomization - to develop active platforms (i.e., monocomponent, protein and drug loaded scaffolds and μ-scaffolds) made of synthetic (PCL, PLGA) or natural (chitosan, alginate) polymers. In particular, we investigate how to set materials and process parameters to impart specific morphological, biochemical or physical cues to trigger all the fundamental cell-biomaterial and cell-cell cross-talking elicited during regenerative processes, in order to reproduce the complex microenvironment of native or pathological tissues.

分类号： o63-532

  • 相关文献

[1]Particle Manipulation Through Polymer Solutions In Microfluidic Processes. F. Del Giudice,G. D'Avino,M.M. Villone,F. Greco,P.L. Maffettone. 2015

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