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Effects on growth and osteogenic differentiation of mesenchymal stem cells by the strontium-added sol-gel hydroxyapatite gel materials

文献类型： 会议论文

第一作者： Maria Grazia Raucci

作者： Maria Grazia Raucci 1 ; Daniela Giugliano 1 ; M.A. Alvarez-Perez 2 ; C. Demitri 3 ; Luigi Ambrosio 1 ;

作者机构： 1.Institute of Polymers, Composites and Biomaterials - National Research Council of Italy. Mostra d'Oltremare Pad.20 - Viale Kennedy 54, 80125 - Naples, Italy

2.Tissue Bioengineering Laboratory; DEPeI, Faculty of Dentistry, National Autonomous University of Mexico, 04510, Mexico DF, Mexico

3.Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy

会议名称： European Conference on Biomaterials

主办单位：

页码： 865-

摘要： In this study, strontium-substituted hydroxyapatite with different Sr content has been synthesized at room temperature by using a sol-gel approach. The strontium incorporated in the hydroxyapatite structure decrease slightly the size of HA nanoparticles as demonstrated by morphological analyses. Moreover, biological results demonstrated that strontium-doped hydroxyapatite gels up 20mol% show good biocompatibility without significative cytotoxic effect. This work confirms the ability of the hydroxyapatite modified Sr materials to induce hMSC differentiation towards the osteoblast-like phenotype.

分类号： Q691

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