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Effect of surfaces properties on bone differentiation in composite scaffolds

文献类型： 会议论文

第一作者： Vincenzo Guarino

作者： Vincenzo Guarino 1 ; Marica Marrese 1 ; Francesca Veronesi 2 ; Paola Torricelli 2 ; Monica Sandri 3 ; Anna Tampieri 3 ; Milena Fini 2 ; Luigi Ambrosio 1 ;

作者机构： 1.Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra D'Oltremare, Pad.20, V.le Kennedy 54, 80125, Naples, Italy

2.Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10, Bologna, Italy

3.CNR - Institute of Science and Technology for Ceramics (ISTEC), Via Granarolo, 64 48018 Faenza (RA) - Italy

会议名称： European Conference on Biomaterials

主办单位：

页码： 715-

摘要： Here we conclude that bioactive fillers with different chemistry and/or shape factors concur to particularize surface properties of composite scaffolds with effects on in vitro cell response. The set of morphological information - roughness, wettability and stiffness programmed into the scaffold surface corroborated by intrinsic bioactive cues of calcium phosphate fillers influence the osteogenic activity of MG63 as confirmed by differences in bone markers data. In comparison with HA loaded surfaces, MgCHA ones confirms a higher biomimeticity level due to the presence of Mg doped apatites which are better recognized by MG63 without production of cytokines, and promote higher ALP synthetic activity related to osteogenic differentiation.

分类号： Q691

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