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DRUG RELEASE FROM BIODEGRADABLE POLYESTERURETHANES WITH SHAPE-MEMORY EFFECT

文献类型： 会议论文

第一作者： Yakai Feng

作者： Yakai Feng 1 ; Shifeng Zhang 2 ; Heyun Wang 2 ; Haiyang Zhao 2 ; Jian Lu 2 ; Jintang Guo 3 ; Marc Behl; Andreas Lendlein;

作者机构： 1.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China,Tianjin University-GKSS Research Centre, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin 300072, China Kantstr.55,14513 Teltow, G

2.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

3.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China,Tianjin University-GKSS Research Centre, Joint Laboratory for Biomaterials and Regenerative M

关键词： polyurethanes;biodegradability;release;shape-memory;dexamethasone

会议名称： Symposium on innovative polymers for controlled delivery

主办单位：

页码： 102-104

摘要： Biodegradable polyesterurethane (PU) networks with shape memory properties have been synthesized and used as controlled release matrix for the model drug dexamethasone (DEX) in phosphate buffered saline pH = 7.0 at 37°C. The drug release courses of DEX could be divided into three stages as a typical erosion-controlled release mechanism. The crosslinking density of PU networks affected both degradation of the polymer networks and drug release rate.

分类号： R318.08`R318.08

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