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BIODEGRADABLE POLYESTERURETHANES WITH SHAPE-MEMORY PROPERTIES FOR DEXAMETHASONE AND ASPIRIN CONTROLLED RELEASE

文献类型： 会议论文

第一作者： Yakai Feng

作者： Yakai Feng 1 ; Shifeng Zhang 2 ; Heyun Wang 2 ; Haiyang Zhao 2 ; Jian Lu 2 ; Jintang Guo 3 ; Marc Behl; Andreas Lendlein;

作者机构： 1.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China,Tianjin University-GKSS Research Centre, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin 300072, China Kantstr.55, 14513 Teltow,

2.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

3.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China,Tianjin University-GKSS Research Centre, Joint Laboratory for Biomaterials and Regenerative

关键词： polyurethanes;biodegradability;release;shape-memory;dexamethasone;aspirin

会议名称： Symposium on innovative polymers for controlled delivery

主办单位：

页码： 105-108

摘要： Biodegradable polyesterurethane (PU) networks with shape memory properties have been synthesized and used as controlled release matrix for dexamethasone (DEX) and aspirin (ASP) in phosphate buffered saline pH = 7.0 at 37 °C. The drug release courses of both model drugs could be divided into three stages as a typical erosion-controlled release mechanism. The crosslinking density affected both degradation of polymer networks and drug release rate. ASP accelerated the degradation process of PU owing to the acidic nature of ASP, which resulted in higher release rate of ASP than DEX.

分类号： R318.08`R318.08

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