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NITRIC OXIDE RELEASE FROM POLYCARBONATE-URETHANE FILMS CONTAINING COPPER(Ⅱ) COMPLEXES

文献类型： 会议论文

第一作者： Yakai Feng

作者： Yakai Feng 1 ; Haiyang Zhao 2 ; Jian Lu 1 ; Jintang Guo 3 ;

作者机构： 1.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China,Tianjin University-GKSS Research Centre, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin 300072, China Kantstr.55, 14513 Teltow,

2.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

3.School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China,Tianjin University-GKSS Research Centre, Joint Laboratory for Biomaterials and Regenerative Medi

关键词： polycarbonate-urethanes;cu(II)-complex;hemocompatibility;NO releasing;blend

会议名称： Symposium on innovative polymers for controlled delivery

主办单位：

页码： 464-466

摘要： NO is a well known potent antiplatelet agent to prevent the adhesion of platelets on artificial blood vessel walls. Polycarbonate-urethane (PCU) films with NO releasing function were prepared by blending with Cu(II)-complex. The PCU film could release NO continually over 2 d, which will provide a promising approach to enable endogenous NO generation on the surface of medical devices. The generation of biologically active levels of NO at the blood/polymer interface can reduce the risk of implant related thrombosis.

分类号： R318.08`R318.08

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