文献类型： 外文期刊
作者： Deng, Lei 1 ; Tan, Kevin S. W. 4 ;
作者机构： 1.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
2.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
3.Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02134 USA
4.Natl Univ Singapore, Hlth Longev Translat Res Programme, Lab Mol & Cellular Parasitol, Singapore 117545, Singapore
5.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore 117545, Singapore
关键词： blastocystis; cardiometabolic health; gut microbiota; immune modulation; tryptophan metabolism
期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）
ISSN：
年卷期： 2025 年 12 卷 17 期
页码：
收录情况： SCI
摘要： Blastocystis, a prevalent eukaryotic microorganism in the gut microbiota, has emerged as a potential link between healthy diets and improved cardiometabolic health. Despite its genetic diversity and varied host interactions, Blastocystis is consistently associated with healthier dietary patterns and reduced risk of cardiometabolic diseases. Current evidence suggests that Blastocystis may influence host metabolism by modulating gut microbial composition, short-chain fatty acids (SCFAs) production, and immune cell differentiation. Moreover, its role in tryptophan metabolism provides intriguing insights into its potential impact on host signaling pathways. However, mechanistic evidence connecting Blastocystis to improved metabolic health remains limited. This perspective explores plausible pathways, including SCFAs-mediated signaling, tryptophan metabolism, and immune modulation, through which Blastocystis may exert its effects. A systematic research framework integrating axenic cultivation, in vitro co-culture systems, animal models, and multi-omics approaches is proposed to further elucidate these mechanisms and expand the understanding of Blastocystis in gut health and disease.
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