文献类型： 外文期刊
作者： Wang, Wenjing 1 ; He, Yumin 1 ; He, Suxiang 1 ; Deng, Lei 5 ; Wang, Hui 6 ; Cao, Zhong 7 ; Feng, Zemeng 1 ; Xiong, Benhai 6 ; Yin, Yulong 1 ;
作者机构： 1.Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Peoples R China
2.Zhongke Jieyun Beijing Informat Technol Co Ltd, Beijing 101400, Peoples R China
3.Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China
4.Hunan Agr Univ, Coll Chem & Mat Sci, Changsha 410128, Peoples R China
5.Cent South Univ, Sch Comp Sci & Engn, Changsha 410075, Peoples R China
6.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
7.Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Hunan Prov Key Lab Cytochem, Changsha 410114, Peoples R China
关键词： peptide; nucleic acid; aptamer; biosensor; review
期刊名称：BIOSENSORS-BASEL （ 影响因子：5.6； 五年影响因子：5.7 ）
ISSN：
年卷期： 2025 年 15 卷 2 期
页码：
收录情况： SCI
摘要： Aptamers have recently become novel probes for biosensors because of their good biocompatibility, strong specificity, and high sensitivity. Biosensors based on peptides or nucleic acid aptamers are used in implantable and wearable devices owing to their ease of synthesis and economic efficiency. Simultaneously, amphoteric ionic peptides are being explored as antifouling layers for biosensors resistant to interference from extraneous proteins in serum. Thus, this paper reviews recently developed aptamer-based biosensors and introduces peptide- and nucleic acid-based biosensors, while focusing on the three primary classes of biosensors: electrochemical sensors, fluorescent or colorimetric biosensors, and electroluminescent sensors. Furthermore, we summarize their general construction strategies, describe specific electrochemical sensors that use peptides as an antipollution layer, and elucidate their advantages.
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