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Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection

文献类型： 外文期刊

作者： Deng, Lei 1 ; Wang, Shaohui 1 ;

作者机构： 1.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai, Peoples R China

2.Broad Inst & Harvard, Infectious Dis & Microbiome Program, Cambridge, MA 02142 USA

3.Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

关键词： Gut microbiota; colonization resistance; Salmonella; immune response; dietary intervention

期刊名称：GUT MICROBES （ 影响因子：11.0； 五年影响因子：13.4 ）

ISSN： 1949-0976

年卷期： 2024 年 16 卷 1 期

页码：

收录情况： SCI

摘要： The human gastrointestinal tract is colonized by a complex microbial ecosystem, the gut microbiota, which is pivotal in maintaining host health and mediating resistance to diseases. This review delineates colonization resistance (CR), a critical defensive mechanism employed by the gut microbiota to safeguard against pathogenic bacterial invasions, notably by Salmonella. We detail the mechanisms through which the gut microbiota impedes Salmonella colonization, including nutrient competition, production of antimicrobial peptides, synthesis of microbial-derived metabolites, and modulation of the host immune response. Additionally, we examine how dietary interventions can influence these mechanisms, thereby augmenting the protective role of the gut microbiota. The review also discusses the sophisticated strategies utilized by Salmonella to overcome these microbial defenses. A thorough understanding of these complex interactions between microbial symbionts and pathogens is crucial for the development of innovative therapeutic strategies that enhance CR, aiming to prevent or treat microbial infections effectively.

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