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Complemented Palindromic Small RNAs First Discovered from SARS Coronavirus

文献类型： 外文期刊

作者： Liu, Chang 1 ; Chen, Ze 2 ; Hu, Yue 1 ; Ji, Haishuo 5 ; Yu, Deshui 5 ; Shen, Wenyuan 1 ; Li, Siyu 5 ; Ruan, Jishou 7 ; Bu, W 1 ;

作者机构： 1.Nankai Univ, Sch Med, Lab Med Mol Virol, Tianjin 300071, Peoples R China

2.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China

3.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, Lanzhou 730046, Gansu, Peoples R China

4.Coinnovat Ctr Prevent & Control Important Anim I, Yangzhou 225009, Jiangsu, Peoples R China

5.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China

6.Nankai Univ, Inst Stat, Tianjin 300071, Peoples R China

7.Nankai Univ, Sch Math Sci, Tianjin 300071, Peoples R China

关键词： palindromic small RNA; complemented palindromic small RNA; small RNA; DNA complemented palindrome; severe acute respiratory syndrome coronavirus

期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）

ISSN： 2073-4425

年卷期： 2018 年 9 卷 9 期

页码：

收录情况： SCI

摘要： In this study, we report for the first time the existence of complemented palindromic small RNAs (cpsRNAs) and propose that cpsRNAs and palindromic small RNAs (psRNAs) constitute a novel class of small RNAs. The first discovered 19-nt cpsRNA UUAACAAGCUUGUUAAAGA, named SARS-CoV-cpsR-19, was detected from a 22-bp DNA complemented palindrome TCTTTAACAAGCTTGTTAAAGA in the severe acute respiratory syndrome coronavirus (SARS-CoV) genome. The phylogenetic analysis supported that this DNA complemented palindrome originated from bat betacoronavirus. The results of RNA interference (RNAi) experiments showed that one 19-nt segment corresponding to SARS-CoV-cpsR-19 significantly induced cell apoptosis. Using this joint analysis of the molecular function and phylogeny, our results suggested that SARS-CoV-cpsR-19 could play a role in SARS-CoV infection or pathogenesis. The discovery of cpsRNAs has paved a way to find novel markers for pathogen detection and to reveal the mechanisms underlying infection or pathogenesis from a different point of view. Researchers can use cpsRNAs to study the infection or pathogenesis of pathogenic viruses when these viruses are not available. The discovery of psRNAs and cpsRNAs, as a novel class of small RNAs, also inspire researchers to investigate DNA palindromes and DNA complemented palindromes with lengths of psRNAs and cpsRNAs in viral genomes.

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