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Mechanism of action and future perspectives of ADCs in combination with immune checkpoint inhibitors for solid tumors

文献类型： 外文期刊

作者： Lv, Yahui 1 ; Cui, Xiaoran 3 ; Li, Tao 1 ; Liu, Chang 1 ; Wang, An 1 ; Wang, Ting 1 ; Zhou, Xin 1 ; Li, Ruixin 1 ; Zhang, Fan 1 ; Hu, Yi 1 ; Zhang, Tong 3 ; Liu, Zhefeng 1 ;

作者机构： 1.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Oncol, Beijing 100853, Peoples R China

2.Minist Educ, Chinese PLA Key Lab Oncol, Key Lab Tumor Targeting Therapy & Antibody Drugs, Beijing, Peoples R China

3.Med Sch Chinese PLA, Beijing 100853, Peoples R China

4.Chinese Peoples Liberat Army PLA Gen Hosp, Med Ctr 5, Dept Hematol, Beijing 100853, Peoples R China

5.First Med Ctr PLA Gen Hosp, Dept Stomatol, Beijing 100853, Peoples R China

6.Chinese Acad Agr Sci, Changchun Vet Res Inst, Key Lab Jilin Prov Zoonosis Prevent & Control, Yujinxiang St 573, Changchun 130122, Jilin, Peoples R China

7.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Oncol, Beijing 100853, Peoples R China

8.Nankai Univ, Sch Med, Tianjin 30071, Peoples R China

关键词： Antibody-drug conjugates; Immunotherapy; Immune checkpoint inhibitors; Solid tumor

期刊名称：CLINICAL AND EXPERIMENTAL MEDICINE （ 影响因子：3.5； 五年影响因子：3.6 ）

ISSN： 1591-8890

年卷期： 2025 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Antibody-drug conjugates (ADCs) are a promising cancer therapy for targeted delivery of drugs to tumor cells. However, resistance to ADCs remains a challenge, necessitating the exploration of combination therapies. A strong biological theory suggests that ADCs interact with cancer cells and immune cells by triggering mechanisms such as immunogenic cell death, dendritic cell activation, and memory T-cell activation, resulting in long-term anti-tumor immunity and ultimately potential synergistic effects with immunotherapy. Based on extensive and reliable preclinical data, several clinical trials are currently combining ADCs with immune checkpoint inhibitors (ICIs) for the treatment of various cancers, including breast, gastric, and non-small-cell lung cancers, to evaluate the safety and anti-tumor activity of the combination therapy. Preliminary evidence from early clinical trials has reported more effective efficacy data. This paper reviews the combination of ADCs and immunotherapy, highlights the key mechanisms by which the two act synergistically, and summarizes the available clinical evidence against different ADCs targets. The paper also explores the re-challenges used for combination therapies and optimized design options for ADCs drugs.

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