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High-phytosterol rapeseed oil prevents atherosclerosis by reducing intestinal barrier dysfunction and cholesterol uptake in ApoE / mice

文献类型： 外文期刊

作者： Xu, Yaxi 1 ; Fang, Mengxue 1 ; Chen, Ze 5 ; Jin, Zhili 5 ; Zhang, Tong 5 ; Yu, Li 1 ; Ma, Fei 1 ; Lu, Zhibing 5 ; Wang, Hairong 5 ; Zhang, Liangxiao 1 ; Li, Peiwu 1 ;

作者机构： 1.Chinese Acad Agr Sci, Key Lab Biol & Genet Improvement Oil Crops, Minist Agr & Rural Affairs, Wuhan 430062, Peoples R China

2.Chinese Acad Agr Sci, Lab Risk Assessment Oilseed Prod Wuhan, Minist Agr & Rural Affairs, Wuhan 430062, Peoples R China

3.Chinese Acad Agr Sci, Qual Inspect & Test Ctr Oilseed Prod, Minist Agr & Rural Affairs, Wuhan 430062, Peoples R China

4.Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China

5.Wuhan Univ, Dept Cardiol, Zhongnan Hosp, Wuhan 430071, Peoples R China

6.Hubei Hongshan Lab, Wuhan 430070, Peoples R China

7.Wuhan Univ, Inst Myocardial Injury & Repair, Wuhan 430071, Peoples R China

8.Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Saf, Nanjing 210023, Peoples R China

9.Chinese Acad Agr Sci, Zhongyuan Res Ctr, Xinxiang 453500, Peoples R China

10.Wuhan Univ, Cardiovasc Inst, Zhongnan Hosp, Wuhan, Peoples R China

11.Xianghu Lab, Hangzhou 311231, Peoples R China

关键词： High-phytosterol rapeseed oil; Intestinal barrier; Atherosclerosis; Cholesterol uptake

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.0； 五年影响因子：8.5 ）

ISSN： 0963-9969

年卷期： 2025 年 214 卷

页码：

收录情况： SCI

摘要： Atherosclerosis (AS) is a chronic vascular disease characterized by the formation of an atherosclerotic plaque and high serum cholesterol. This study focused on the role of intestinal cholesterol uptake and barrier integrity of AS mice to investigate the anti-AS mechanism of high-phytosterol rapeseed oil (HPRO). The results showed that HPRO exhibited a significant anti-AS effect, which significantly reduced aortic plaque and serum cholesterol content, and increased aortic diameter. The comprehensive analysis of transcriptomic and metabolomic analysis on the intestine showed that HPRO mainly regulated primary bile acid biosynthesis and cholesterol metabolism. Interestingly, HPRO was found to reduce cholesterol absorption, transport, and micellar cholesterol content in the intestine, and the effect of HPRO was better than beta-sitosterol. In addition, the expression of ZO-1 and occludin increased in both Caco-2 cells and the mice intestine, suggesting that HPRO can improve intestinal barrier function. Overall, these findings suggested that HPRO showed a significant preventative action on AS by reducing intestinal barrier and cholesterol intake dysfunction.

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