Advances and Future Perspectives of HER2 Mutations in Non-Small Lung Cancer (NSCLC), Especially in China
文献类型： 外文期刊
作者： Liu, Chang 1 ; Li, Tao 1 ; Cui, Xiaoran 4 ; Lv, Yahui 1 ; Liu, Min 4 ; Zhou, Xin 1 ; Yang, Fan 1 ; Dong, Yi 1 ; Li, Ruixin 1 ; Zhang, Fan 1 ; Zhang, Tong 4 ; Hu, Yi 1 ;
作者机构： 1.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Sr Dept Oncol, Beijing 100853, Peoples R China
2.Minist Educ, Chinese PLA Key Lab Oncol, Key Lab Tumor Targeting Therapy & Antibody Drugs, Beijing, Peoples R China
3.Nankai Univ, Sch Med, Tianjin, Peoples R China
4.Med Sch Chinese PLA, Beijing, Peoples R China
5.Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Stomatol, Beijing 100853, Peoples R China
6.Chinese Acad Agr Sci, Changchun Vet Res Inst, Key Lab Jilin Prov Zoonosis Prevent & Control, Jilin, Peoples R China
7.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Sr Dept Oncol, Beijing, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Med Supplies Ctr, Dept Pharm, Beijing, Peoples R China
关键词： HER2; Non-small lung cancer (NSCLC); China
期刊名称：CANCER CONTROL （ 影响因子：2.6； 五年影响因子：2.7 ）
ISSN： 1073-2748
年卷期： 2025 年 32 卷
页码：
收录情况： SCI
摘要： HER2-mutated non-small lung cancer (NSCLC) in China represents a substantial patient population characterized by an unfavorable prognosis. However, at present, the main clinical treatment options are relatively limited. HER2 mutations in Chinese NSCLC (2019-2024) demonstrated 3.8%-5.6% prevalence via NGS, exceeding global baselines, with superior detection vs PCR (4.5% vs 3.1%). In addition, more attention was paid to molecular analysis and the detection rate of HER2 genomic alterations in NSCLC patients in eastern and northern China compared to other parts of China, which might be related to regional economic differences and geographic differences in lung cancer epidemiology. The evolving therapeutic landscape has established new-generation TKIs (pyrotinib) and antibody-drug conjugates (ADCs) like trastuzumab deruxtecan (T-Dxd) as targeted strategies for HER2-mutant NSCLC. Despite late research initiation, China rapidly advanced from retrospective analyses to pioneering new drug trials. In general, the incidence of HER2-mutated NSCLC in the Chinese population seems to be higher than the world average, and there is a large number of missed HER2-mutated NSCLC patients in China. In this field, ADCs and novel TKIs are being developed and researched in spurts, and new drugs are moving from back-line therapy to front-line therapy, and from single-drug regimens to combination regimens.
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