Probing Multiscale Cell-Biomatcrial Interactions via Confocal/Multiphoton Imaging and X-ray μC-Tomography
文献类型： 会议论文
第一作者： Matthew D. Treiser
作者： Matthew D. Treiser 1 ; Patrick Johnson; Robert A. Dubin; Aarti Rege; David Denhardt; Joachim Kohn; Prabhas Moghe; Society for Biomaterials;;
作者机构： 1.The New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ 08854
会议名称： Society for Biomaterials Transaction of the 31st Annual Meeting vol.XXIX pt.2
主办单位：
页码： 676-
摘要： Our studies exploit the complementary size scales via confocal and multi-photon imaging and MicroCT as modalities for the detailed analysis of scaffold architecture at the macroscopic, mesoscopic and microscopic levels. Analysis of living cells growing on polymer surfaces was demonstrated, providing a setup for the in situ study of cell morphometric and phenotypic responses to biomaterials. Our early data suggests that the addition of PEG in the backbone will decrease cell attachment and proliferation, of cells, but increase metabolic activity and differentiation, which, in turn, may be offset by the minute incorporation of iodine. In addition, the use of genetically engineered cells may provide a means of visualizing alterations in cytoskeletal elements in living, non-fixed, cells on polymer scaffold surfaces to further elucidate how polymer architecture and chemistry mediate cellular responses.
分类号： R318.08
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