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DISTINCT BIOPHYSICAL CHANGES CAUSED BY THE ADDITION OF IODINE ATOMS IN DEGRADABLE AMORPHOUS BIOMATERIALS

文献类型： 会议论文

第一作者： Khaled A.Aamer

作者： Khaled A.Aamer 1 ; Joachim Kohn 2 ; Matthew L Becker 3 ;

作者机构： 1.Polymers Division, NIST, Gaithersburg, MD 20899

2.New Jersey Center for Biomaterials, Piscataway, NJ 08854

3.Department of Polymer Science, University of Akron, 170 University Ave

会议名称： International symposium on polymer physics

主办单位：

页码： 117-117

摘要： @@X-ray based fluoroscopy and imaging are the preferred imaging modalities for assessing correct device placement and function following surgical implantation. Imaging polymeric constructs under clinically preferred conditions is complicated in that most polymeric materials are amorphous and possess very low X-ray scattering cross-sections. Iodine is routinely incorporated into amorphous polymeric materials to increase the X-ray contrast' but this process cause distinct physico-chemical changes in the material, which in turn can have a variety of biological implications, including changing the nature of the adsorbed protein layer. To assess influence of iodine incorporation of the cellbiomaterial interactions including protein adsorption, a blending strategy was designed to minimizing the amount of iodine necessary within the polymers for X-ray based imaging.

分类号： O63`O63

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