Cell Morphogenesis and Organization on Electrospun Scaffolds is Guided by Varying Porosity and Fiber Diameter
文献类型： 会议论文
第一作者： Charles A. Florek
作者： Charles A. Florek 1 ; Patrick A. Johnson; Prabhas V. Moghe; Joachim Kohn; Society for Biomaterials;;
作者机构： 1.New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854, USA
会议名称： Society for Biomaterials Transaction of the 31st Annual Meeting vol.XXIX pt.1
主办单位：
页码： 358-
摘要： The electrospun scaffolds had varying fiber diameter, which in turn controlled the inter-fiber porosity. Scaffolds of 0.29 μm clearly excluded firoblast infiltration. Results were inconclusive for the 0.54 μm fiber diameters, while the scaffolds with larger fiber diameters clearly facilitated the infiltration of cells into the scaffold. Our observations indicated that fiber mats must have fiber diameters of about 0.3 μm or below to be used for the prevention of surgical adhesions. Further work is under way to examine the degree of macrophage activation on the scaffolds with variable porosity.
分类号： R318.08
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