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Biodegradable NovoSorb™ Polymers: Structure/Property Relationships & In-vitro/In-vivo Degradation

文献类型: 会议论文

第一作者: Mayadunne R. T. A.

作者: Mayadunne R. T. A. 1 ; Gunatillake P. A.; Adhikari, R.; Griffiths I. M.; Field J. R.; Houshyar S.; Hanu L.; Menzis D.; Moore T.; Johnston P.; Tatai L.; Wickramarathna M.; Society for Biomaterials;;

作者机构: 1.PolyNovo Biomaterials Pty Ltd, Bag 10, Clayton South, Victoria 3168, Australia

会议名称: Society for Biomaterials Transaction of the 31st Annual Meeting vol.XXIX pt.2

主办单位:

页码: 494-

摘要: Hydrolytically degradable synthetic polymers have found extensive use in medical implants. Of those currently used homo and co-polyesters of lactic and/or glycolic acids have largely been exploited over the years due to their excellent inherent properties. Their ability to degrade to biocompatible molecules, the ease with which these fragments are resorbed and removed by the body is seen as the major advantage. Consequently, these polymers have been used in many applications including resorbable sutures drug delivery systems, and orthopaedic fixation devices such as pins, rod and screws. We have evaluated the potential use of a family of biodegradable ester-polyurethane blends, formulated for orthopaedic applications and trademarked as NovoSorb™. These pre-polymers have an injectable consistency, enabling them to be delivered to the defect site by arthroscopy and cured in-situ (in-situ Cure, ISC) or on demand (cure on demand, COD), depending on the application at hand. The paper describes the polymer structure, their properties, in-vitro and in-vivo degradation studies carried out so far.

分类号: R318.08

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