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ECG Morphology-Based Markers for Risk Stratification in Hypertrophic Cardiomyopathy

文献类型： 会议论文

第一作者： Inés Noguero-Soler

作者： Inés Noguero-Soler 1 ; Javier Ramos-Maqueda 2 ; Pablo Revilla-Martí 2 ; Esther Pueyo 3 ; Ana Mincholé 3 ;

作者机构： 1.BSICoS, I3A, IIS Aragón, University of Zaragoza, Zaragoza, Spain|University of Zaragoza

2.Clinical Hospital Lozano Blesa, Zaragoza, Spain

3.BSICoS, I3A, IIS Aragón, University of Zaragoza, Zaragoza, Spain|CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain

关键词： Time series analysis;Morphology;Electrocardiography;Death;Recording;Risk management;Cardiology

会议名称： Computing in Cardiology Conference

主办单位：

页码： 1-4

摘要： Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death in young adults. Current risk markers for this heterogeneous disease lack performance and, thus, new approaches are needed. This study aims to enhance our understanding of risk assessment in HCM patients analyzing ECG-based markers in 24-hour Holter signals in a retrospective study dividing patients in asymptomatic, at-risk of a cardiac event and after a cardiac event. We studied conventional ECG markers such as RR interval, QRS width (QRSw) and corrected QT and T-peak-to-T-end intervals, which were computed for each patient from representative median beats every hour. First, the median marker values in the 24 hours were compared between groups. Second, variations in these markers between day and night were studied. All patients showed marked circadian variations in RR and QT time series. Patients at risk of suffering cardiac events were found to have wider QRS complexes, with statistically significant differences between day and night. This QRS prolongation in HCM patients, occurring months before suffering a cardiac event, might indicate anomalies in ventricular conduction. Regarding day-night variations, these were slightly greater in patients before an event. This work provides new evidence on ECG-based markers and encourages further research on QRS-wave and T-wave assessment.

分类号： tp3

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