您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

An in Silico Investigation Into The Role of SK Channels in Failing Ventricular Myocytes

文献类型： 会议论文

第一作者： Marta Gomez

作者： Marta Gomez 1 ; Jesus Carro 1 ; Esther Pueyo 2 ; Violeta Monasterio 1 ;

作者机构： 1.Universidad San Jorge, Villanueva de Gallego, Spain

2.Aragon Institute for Engineering Research, University of Zaragoza, IIS Aragon, Spain|CIBER in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), Spain

关键词： Electric potential;Action potentials;Computational modeling;Electrophysiology;Mathematical models;Cardiology;Potassium

会议名称： Computing in Cardiology Conference

主办单位：

页码： 1-4

摘要： SK channels are small conductance (~10 pS) calcium-activated potassium channels. Although they have been suggested not to play a relevant role in healthy ventricles, SK channel upregulation has been reported in failing ventricles, with potential implications for arrhythmogenesis. In this work, we aimed at uncovering the contribution of SK channels to ventricular repolarization in failing myocytes. To that end, we extended an in silico electrophysiological model of human ventricular failing myocytes by introducing the equations representing SK channel activity. To determine the value of the maximal SK current conductance, GSK’ we simulated action potentials (APs) at different pacing frequencies and we fitted the changes in AP duration induced by SK channel inhibitions to available experimental data recorded under pharmacological inter-ventions. The SK block-induced effects in our simulations were consistent with experimental evidence. Early after-depolarizations were observed at pacing frequencies below 0.7 Hz only when SK channels were blocked. In conclusion, our presented model of human ventricular failing myocytes integrating an SK channel formulation can allow dissecting the contribution of SK channels to ventricular repolarization and may help in understanding their role in arrhythmogenesis.

分类号： tp3

  • 相关文献

[1]QRS Width and T-Peak to T-End Interval Are Prolonged in Preadolescents with Severe Intrauterine Growth Restriction at Birth when Compared to Controls. Freddy L Bueno–Palomeque,Konstantinos A Mountris,Nuria Ortigosa,Raquel Bailón,Bart Bijnens,Fàtima Crispi,Esther Pueyo,Ana Mincholé,Pablo Laguna. 2023

[2]Accelerating Stabilization of Whole-heart Models after Changes in Cycle Length. Hassaan A Bukhari,Carlos Sánchez,Esther Pueyo,Mark Potse. 2022

[3]Behavioral and electrophysiological responses of natural enemies to synomones from tea shoots and kairomones from tea aphids, Toxoptera aurantii. Han, BY,Chen, ZM. 2002

[4]Assessment of grassland degradation in Guinan county, Qinghai Province, China, in the past 30 years. Feng, Y.,Lu, Q.,Wang, X.,Tokola, T.,Liu, H..

[5]In Silico Assessment of Arrhythmic Risk in Infarcted Ventricles Engrafted with Engineered Heart Tissues. Ricardo M Rosales,Konstantinos A Mountris,Manuel Doblare,Manuel M Mazo,Esther Pueyo. 2023

[6]Detection of acetone in milk through odor towards monitoring of ketosis in dairy cows. Kosuke Minami,Masaaki Matoba,Ryoh Nakakubo,Genki Yoshikawa. 2024

[7]Toward the quantification of adeno-associated virus titer by electrochemical impedance spectroscopy. Junhyeong Wang,Mahshid Hosseini,Shriarjun Shastry,Eduardo Barbieri,Wenning Chu,Stefano Menegatti,Michael A. Daniele. 2023

[8]Optimizing Onset and Offset Detection in Surface Diaphragm Electromyographic Signals: A Signal Quality-Driven Approach. Abel Torres,Luis Estrada-Petrocelli,Tim Raveling,Marieke L Duiverman. 2024

[9]Cross-subject Drowsiness Recognition Model Based on the Multi-scale Parallel Convolution of EEG Channels. Shaohua Wan,Songquan Li,Rongbo Zhu,Jun Yuan. 2023

[10]Nutrient dynamics in a dryland corn cropping system in Northern China: Effects of crop residue, animal manure and NP fertilizer applications. X. B. Wang,D. X. Cai,O. Oenema,W. B. Hoogmoed,U. D. Perdok. 2005

[11]Rapid analysis of potassium content in cotton stalks of Ch using laser-induced breakdown spectroscopy. Shuangshuang Ma,Lujia Han,Guangqun Huang. 2018

[12]Productivity and quality response of tea to balanced nutrient management - Examples from China tea gardens. J. Ruan,R. Hardter. 2001

[13]Coverage of PPG-Based Wearable Devices in Office Tasks. Francesco Ferrati,Eduardo Gil,Jesús Lázaro. 2023

[14]ECG Morphology-Based Markers for Risk Stratification in Hypertrophic Cardiomyopathy. Inés Noguero-Soler,Javier Ramos-Maqueda,Pablo Revilla-Martí,Esther Pueyo,Ana Mincholé. 2023

[15]Spatial Dispersion of Activation and Repolarization Times Associated with Different Cardiac Pacing Modes. Juan Pablo Martínez,Esther Pueyo,Saúl Palacios,Radovan Smisek,Karol Curila,Uyen Nguyen,Frits W Prinzen,Josef Halamek,Filip Plesinger,Pavel Jurak. 2023

[16]Left Bundle Branch Area Pacing Generates More Physiological Ventricular Activation Sequences than Right Ventricular Pacing. Clara Sales,Ana Mincholé,Jorge Melero-Polo,Mercedes Cabrera-Ramos,Isabel Montilla-Padilla,Laura Sorinas,Ines Julián,Esther Pueyo,Javier Ramos. 2023

[17]ECG-Based Characterization of Acute Ischemia During Percutaneous Coronary Intervention. Jimena Rodríguez-Carbó,Ana Mincholé,Esther Pueyo. 2023

[18]Long-term pig manure application reduces the requirement of chemical phosphorus and potassium in two rice-wheat sites in subtropical China. Xu, M.,He, X.,He, X.,He, X.,He, X.,Li, S.,Sun, X.. 2011

[19]Nitrogen use efficiency in a wheat-corn cropping system from 15 years of manure and fertilizer applications. Duan, Yinghua,Xu, Minggang,Liu, Hongbin,Wang, Bairen,Gao, Suduan,Yang, Xueyun,Huang, Shaomin. 2014

[20]Effects of potassium and magnesium nutrition on the quality components of different types of tea. Ruan, JY,Wu, X,Hardter, R. 1999

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台