您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Accelerating Stabilization of Whole-heart Models after Changes in Cycle Length

文献类型： 会议论文

第一作者： Hassaan A Bukhari

作者： Hassaan A Bukhari 1 ; Carlos Sánchez 2 ; Esther Pueyo 2 ; Mark Potse 3 ;

作者机构： 1.I3A, University of Zaragoza, IIS Aragón, Zaragoza, Spain|CIBER en Bioingeniería, Biomateriales y Nanomedicina, Spain|Carmen team, Inria Bordeaux - Sud-Ouest, Talence, France|Univ. Bordeaux, IMB, UMR, Talence, France

2.I3A, University of Zaragoza, IIS Aragón, Zaragoza, Spain|CIBER en Bioingeniería, Biomateriales y Nanomedicina, Spain

3.Carmen team, Inria Bordeaux - Sud-Ouest, Talence, France|Univ. Bordeaux, IMB, UMR, Talence, France

关键词： Costs;Sodium;Computational modeling;Cardiology

会议名称： Computing in Cardiology Conference

主办单位：

页码： 1-4

摘要： Parameter changes can cause long-term drift in membrane models. To reduce the cost of whole-heart simulations with such changes the stabilization can be performed in isolated-cell models, but it can then still take many beats to stabilize the full model. We hypothesized that differences in activation time leading to cycle length (CL) variability before the first beat contribute to this. To remove this variability we froze most state variables of the model until the sodium current activated. Simulations were performed with CL 400, 500, 600 and 1000 ms and modified Ten Tusscher-Panfilov 2006 dynamics. Isolated endocardial, mid-myocardial, and epicardial cells were simulated for 1000 beats. Their final states were then copied to a model of the whole human ventricles, which was run for 5 beats, with and without freezing. Stabilization of the full model took three to four beats. Freezing of the membrane state accelerated stabilization in some cell types but caused opposite drifts in others. Drifts were largest in the epicardial and mid-myocardial layers, and not in particular at their interfaces. Freezing of membrane state may help to accelerate stabilization but in our scenarios other types of drift dominate and may be aggravated by freezing, as it inhibits electrotonic interactions.

分类号： tp3

  • 相关文献

[1]An in Silico Investigation Into The Role of SK Channels in Failing Ventricular Myocytes. Marta Gomez,Jesus Carro,Esther Pueyo,Violeta Monasterio. 2022

[2]QRS Width and T-Peak to T-End Interval Are Prolonged in Preadolescents with Severe Intrauterine Growth Restriction at Birth when Compared to Controls. Freddy L Bueno–Palomeque,Konstantinos A Mountris,Nuria Ortigosa,Raquel Bailón,Bart Bijnens,Fàtima Crispi,Esther Pueyo,Ana Mincholé,Pablo Laguna. 2023

[3]Agricultural vulnerability and adaptation in developing countries: the Asia-Pacific region. Luo, QY,Lin, E.

[4]GmSALT3, Which Confers Improved Soybean Salt Tolerance in the Field, Increases Leaf Cl- Exclusion Prior to Na+ Exclusion But Does Not Improve Early Vigor under Salinity. Liu, Ying,Yu, Lili,Chen, Jingling,Liu, Xiexiang,Hong, Huilong,Liu, Zhangxiong,Chang, Ruzhen,Qiu, Lijuan,Guan, Rongxia,Qu, Yue,Gilliham, Matthew,Qu, Yue,Gilliham, Matthew. 2016

[5]Cloning and expression analysis of a vacuolar Na+/H+ antiporter gene from Alfalfa. Yang, QC,Wu, MS,Wang, PQ,Kang, JM,Zhou, XL.

[6]Mechanisms of stress tolerance in xerophyte Zygophyllum xanthoxylum and their application in genetic improvement of legume forages. Suo-Min Wang,Ai-Ke Bao,Qing Ma,Li-jun Yue,Jin-Lin Zhang,Guo-Qiang Wu,Jie-Jun Xi,Yan-Wen Wang. 2013

[7]Coverage of PPG-Based Wearable Devices in Office Tasks. Francesco Ferrati,Eduardo Gil,Jesús Lázaro. 2023

[8]ECG Morphology-Based Markers for Risk Stratification in Hypertrophic Cardiomyopathy. Inés Noguero-Soler,Javier Ramos-Maqueda,Pablo Revilla-Martí,Esther Pueyo,Ana Mincholé. 2023

[9]Spatial Dispersion of Activation and Repolarization Times Associated with Different Cardiac Pacing Modes. Juan Pablo Martínez,Esther Pueyo,Saúl Palacios,Radovan Smisek,Karol Curila,Uyen Nguyen,Frits W Prinzen,Josef Halamek,Filip Plesinger,Pavel Jurak. 2023

[10]Left Bundle Branch Area Pacing Generates More Physiological Ventricular Activation Sequences than Right Ventricular Pacing. Clara Sales,Ana Mincholé,Jorge Melero-Polo,Mercedes Cabrera-Ramos,Isabel Montilla-Padilla,Laura Sorinas,Ines Julián,Esther Pueyo,Javier Ramos. 2023

[11]ECG-Based Characterization of Acute Ischemia During Percutaneous Coronary Intervention. Jimena Rodríguez-Carbó,Ana Mincholé,Esther Pueyo. 2023

[12]Quality Supervision of Large and Complex Aerospace Engineering Projects. Bo Duan,Gang Wu,Mingfang Dong,Yu Liu. 2023

[13]Apple bagging system based on machine vision and multi-factor discrimination. Peigang Wei,Wei Sun,Shanshan Cao,Jifang Liu,Fantao Kong. 2023

[14]S2BIOM DATABASE WITH LOGISTICAL COMPONENTS OF THE BIOMASS VALUE CHAIN. Bert Annevelink,Hugo de Groot,Nilay Shah,Sara Giarola,Marco Pantaleo,Perttu Anttila,Martijn Vis,Rik te Raa,Douwe van den Berg,Beno?t Gabrielle,David Sanchez Gonzalez,Daniel García Galindo,?pela ??ap,Nike Krajnc. 2015

[15]A High-Resolution Grassland Aboveground Biomass Estimation Method Based on SfM and Grassland Height Factor. Mengdi Cao,Shanshan Cao,Wei Sun,Fantao Kong. 2023

[16]Review of Reinforcement Learning-Based Control Algorithms in Artificial Pancreas Systems for Diabetes Mellitus Management. Lehel Dénes-Fazakas,Gy?z? Dénes Fazakas,Gy?rgy Eigner,Levente Kovács,László Szilágyi. 2024

[17]CDOD-NET: A Crop Disease Object Detection Model Based on Haar Wavelet Network. Yunpeng Zhao,Shansong Wang,Qingtian Zeng,Weijian Ni,Hua Duan,Nengfu Xie,Fengjin Xiao. 2024

[18]Inter-individual Differences in Cell Composition across the Ventricular Wall May Explain Variability in ECG Response to Serum Potassium and Calcium Variations. Hassaan A Bukhari,Carlos Sánchez,Pablo Laguna,Mark Potse,Esther Pueyo. 2022

[19]Efficient Neural Clustering and Compression of Strings Through Approximate Euclidean Embeddings of the Levenshtein Distance. ünsal ?ztürk,Utku G?rkem Ertürk,Simone Casale-Brunet,Paolo Ribeca,Marco Mattavelli. 2024

[20]Translating Hungarian language dialects using natural language processing models. Barbara Simon,ádám Hartveg,Lehel Dénes-Fazakas,Gy?rgy Eigner,László Szilágyi. 2023

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台