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Ventricular Conduction System Modeling for Electrophysiological Simulation of the Porcine Heart

文献类型： 会议论文

第一作者： Ricardo M Rosales

作者： Ricardo M Rosales 1 ; Konstantinos A Mountris 2 ; Manuel Doblaré 1 ; Manuel M Mazo 3 ; Esther Pueyo 1 ;

作者机构： 1.Aragon Institute of Engineering Research, University of Zaragoza, IIS Aragón, Zaragoza, Spain|CIBER de Bioingeniería Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Spain

2.Mechanical Engineering, University College London, London, United Kingdom

3.Regenerative Medicine Program, CIMA Universidad de Navarra, Pamplona, Spain|Hematology and Cell Therapy, Clínica Universidad de Navarra, Pamplona, Spain

关键词： Heart;Histopathology;Computational modeling;Biological system modeling;Magnetic resonance;Manuals;Systems modeling

会议名称： Computing in Cardiology Conference

主办单位：

页码： 1-4

摘要： Depolarization sequences triggering mechanical contraction of the heart are largely determined by the cardiac conduction system $(CS)$. Many biophysical models of cardiac electrophysiology still have poor representations of the $CS$. This work proposes a semiautomatic method for the generation of an anatomically-realistic porcine $CS$ that reproduces ventricular activation properties in swine computational models. Personalized swine biventricular models were built from magnetic resonance images. Electrical propagation was described by the monodomain model. The $CS$ was defined from manually-determined anatomic landmarks using geodesic paths and a fractal tree algorithm. Two $CS$ distributions were defined, one restricted to the subendocardium and another one by performing a subendo-to-intramyocardium projection based on histological porcine data. Depolarization patterns as well as left ventricular transmural and inter-ventricular delays were assessed to describe ventricular activation by the two $CS$ distributions. The electrical excitations calculated using the two $CS$ distributions were in good agreement with reported activation patterns. The pig-specific subendo-intramyocardial $CS$ led to improved reproduction of experimental activation delays in ventricular endocardium and epicardium.

分类号： tp3

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