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Protein nano-carriers from clicked glycosaminoglycan block copolymers

文献类型： 会议论文

第一作者： Ramon Novoa-Carballal

作者： Ramon Novoa-Carballal 1 ; Carla Silva 1 ; Stephanie Moller 2 ; Matthias Schnabelrauch 2 ; Rui L. Reis 1 ; Iva Pashkuleva 1 ;

作者机构： 1.3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimaraes, Portugal

2.Biomaterials Department, INNOVENT e.V., Pruessingstrasse 27 B, 07745 Jena, Germany

会议名称： European Conference on Biomaterials

主办单位：

页码： 418-

摘要： The ability of sulphated GAG-b-PEG copolymers to carry positively charged proteins has been demonstrated by their assembly with poly-L-lysine as a model protein. The formed IPECs have neutral charge, nanometric size and stability at physiological ionic strength - properties that contribute to prolonged blood circulation times and thus, more effective delivery to the targeted site. Moreover, the complexation with basic fibroblast growth factor (FGF-2) demonstrates the feasibility of these copolymers for proteins encapsulation. These properties together with the possibility for tunable size emphasise the enormous potential of sulfated GAG-b-PEG copolymers for the engineering of delivery systems for positively charged proteins.

分类号： Q691

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