文献类型： 会议论文

第一作者： Andreas Hoene

作者： Andreas Hoene ¹ ; Matthias Schnabelrauch ² ; Ralf Wyrwa ² ; Birgit Finke ³ ; Silke Lucke ⁴ ; Uwe Walschus ⁴ ; Michael Schlosser ⁴ ;

作者机构： 1.Department of Surgery, University Medical Center Greifswald, Germany

2.Biomaterials Department, INNOVENT e.V., Jena, Germany

3.Leibniz Institute for Plasma Science and Technology, Greifswald, Germany

4.Department of Medical Biochemistry and Molecular Biology, University Medical Center Greifswald, Germany

会议名称： European Conference on Biomaterials

主办单位：

页码： 667-

摘要： All examined local inflammatory reactions were comparable for the PLA and PLA-P meshes, demonstrating that PPAAm did not negatively affect the tissue response. Compared to the peri-material tissue, the mesh-infiltrating tissue had a stronger response of pro-inflammatory CD68+ monocytes/macrophages, however declining until day 56. In contrast, anti-inflammtory CD 163-positive tissue macrophages decreased in the peri-material tissue and increased in the mesh-infiltrating tissue, accompanied by increasing nestin expression indicating tissue regeneration. Additionally, no differences were found for all other cellular markers. Together with the cell-adhesive effects of PPAAm demonstrated earlier in vitro and recent data regarding PPAAm-coated titanium surfaces in vivo, these results illustrate a general potential for PPAAm as a cell-adhesive biocompatible implant coating.

分类号： Q691