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H5N1 virus invades the mammary glands of dairy cattle through 'mouth-to-teat' transmission

文献类型： 外文期刊

作者： Shi, Jianzhong 1 ; Kong, Huihui 1 ; Cui, Pengfei 1 ; Deng, Guohua 1 ; Zeng, Xianying 1 ; Jiang, Yongping 1 ; He, Xijun 2 ; Zhang, Xianfeng 2 ; Chen, Lei 1 ; Zhuang, Yichao 1 ; Wang, Yan 1 ; Ma, Jinming 1 ; Li, Jiaqi 1 ; Zhang, Yaping 1 ; Wang, Congcong 1 ; He, Chen 1 ; Yang, Jiaxin 1 ; Li, Jiongjie 1 ; Liu, Wenyu 1 ; Yang, Jinyu 3 ; Mao, Shenggang 3 ; Liu, Jinxiong 1 ; Chen, Pucheng 1 ; Tian, Guobin 1 ; Li, Chengjun 1 ; Guan, Yuntao 2 ; Bu, Zhigao 1 ; Chen, Hualan 1 ;

作者机构： 1.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Anim Dis Control, Harbin 150069, Peoples R China

2.Natl High Containment Lab Anim Dis Control & Preve, Harbin 150069, Peoples R China

3.Harbin Weike Biotechnol Co Ltd, Harbin 150069, Peoples R China

关键词： dairy cattle; replication; transmission; vaccination

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：17.1； 五年影响因子：17.7 ）

ISSN： 2095-5138

年卷期： 2025 年 12 卷 9 期

页码：

收录情况： SCI

摘要： H5N1 influenza outbreaks have been reported on more than 1070 dairy farms across 17 states in the USA. Damage to the mammary gland and high levels of virus in milk were common features of the infected cattle, but it is unclear how the virus initially invades the mammary glands, and no control strategy is currently available. Here, we found that cattle oral tissues support H5N1 virus binding and replication, and virus replicating in the mouth of cattle transmitted to the mammary glands of dairy cattle during sucking. We also found that an H5 inactivated vaccine or a hemagglutinin-based DNA vaccine induced sterilizing immunity in cows against challenges with different H5N1 viruses. Our study provides insights into H5N1 virus transmission and control in cattle.

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