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Nanoporous Zeolite Anchored Cellulose Nanofiber Aerogel for Safe and Efficient Hemostasis

文献类型： 外文期刊

作者： Chen, Lei 1 ; Jin, Zhiping 1 ; Kamiya, Takumi 1 ; Liu, Xiaodi 1 ; Tian, Yichen 1 ; Xia, Ruicai 1 ; Wang, Guodong 2 ; Li, Tao 3 ; Zhang, Qiang 1 ;

作者机构： 1.East China Normal Univ, Sch Life Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China

2.Naval Med Univ, Changzheng Hosp, Dept Stomatol, Shanghai 200003, Peoples R China

3.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

关键词： cellulose nanofiber aerogel; hemostasis; low loading ratio; nanoporous zeolite; tightly bonding

期刊名称：SMALL （ 影响因子：12.1； 五年影响因子：12.5 ）

ISSN： 1613-6810

年卷期： 2025 年 21 卷 21 期

页码：

收录情况： SCI

摘要： Clay-based hemostatic materials are commercially available devices designed to control massive bleeding. However, their widespread application is hindered by concerns related to material safety and hemostatic efficacy. In this study, a hemostatic aerogel composed of cellulose nanofibers (CNFs) and Calcium ion-exchanged nanoporous zeolite is developed. CNFs facilitate the in-situ synthesis of nanoporous zeolites, and the zeolites are firmly embedded within the aerogel through abundant hydrogen bonds. Notably, the zeolite loading in the aerogel is only 2.89 wt.%, significantly lower than the 18.76 wt.% kaolin content in QuikClot combat gauze. Despite the low loading, the nanoporous zeolites exhibit high efficiency in promoting prothrombin-to-thrombin conversion and accelerating blood clotting. The reduced zeolite content, combined with its strong binding to the aerogel matrix, minimizes the risks of exothermic burns and detached particle-induced distal thrombosis. The animal experiments reveal that the aerogel rapidly controls severe femoral artery bleeding and substantially reduces blood loss. This study presents a novel formulation of zeolite-based hemostatic materials, offering remarkable improvements in both safety and efficacy.

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