ANG-Modified Liposomes Coloaded With α-Melittin and Resveratrol Induce Apoptosis and Pyroptosis in Glioblastoma Cells by Impeding Wnt/β-Catenin Signaling
文献类型： 外文期刊
作者： Zhang, Hai-Qian 1 ; Wang, Yan 1 ; Geng, Xiao 1 ; Dong, Mingxin 1 ; Liu, Ziwei 2 ; Sun, Chengbiao 1 ; Yu, Kaikai 1 ; Xin, Wenwen 3 ; Xu, Ye 4 ; Xu, Na 4 ; Liu, Wensen 1 ;
作者机构： 1.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun, Peoples R China
2.Second Hosp Jilin Univ, Changchun, Peoples R China
3.Acad Mil Med Sci, Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China
4.Jilin Med Univ, Basic Coll Med, Jilin, Peoples R China
关键词： alpha-Melittin; combination therapy; glioblastoma; pyroptosis; resveratrol; Wnt/beta-catenin signaling pathway
期刊名称：CNS NEUROSCIENCE & THERAPEUTICS （ 影响因子：5.0； 五年影响因子：5.8 ）
ISSN： 1755-5930
年卷期： 2025 年 31 卷 5 期
页码：
收录情况： SCI
摘要： Main ProblemGlioblastoma (GB) is one of the most prevalent and devastating types of brain cancer for which efficient treatments are currently lacking because of limitations such as antitumor efficacy, brain delivery, tumor selectivity, and drug resistance. A promising strategy to overcome these obstacles is developing anticancer agents that can be delivered to GB tissues to inhibit tumors with low toxicity to normal brain tissue.MethodsWe developed liposomes encapsulating resveratrol (RES), a polyphenolic compound, and alpha-melittin (alpha-MEL), which is composed of melittin conjugated with an amphiphilic alpha-helical peptide at its N-terminus. RES-, alpha-MEL-, and alpha-MEL-RES-loaded liposomes (Lips) were modified with Angiopep-2 (ANG). The effects of the above liposomes on GB cells were assessed, and the possible mechanisms were analyzed.ResultsANG-modified alpha-MEL-RES-Lips treatment facilitated the passage of these agents through the blood-brain barrier (BBB), increased tumor targeting, and significantly reduced alpha-MEL-associated hemolysis. The combined management of alpha-MEL with RES impeded GB cell growth and prolonged the lifespan of GB tumor-bearing model mice. alpha-MEL-RES-Lips treatment triggered GB cell apoptosis and induced pyroptosis-associated protein expressions of gasdermin-D (GSDMD), gasdermin E (GSDME), cleaved caspase 3, and NLR family pyrin domain containing 3 (NLRP3), and inhibited epithelial-mesenchymal transition (EMT) by modulating the Wnt/beta-catenin signaling pathway.ConclusionANG-modified alpha-MEL-RES-Lips might be a potential nanosystem for GB therapy, and polyphenolic compounds combined with antimicrobial peptides may promote the induction of apoptosis, pyroptosis, and the apoptosis-pyroptosis switch in GB.
- 相关文献
作者其他论文 更多>>
-
Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus
作者：Zhang, Shunfen;Zhong, Ruqing;Li, Kai;Wang, Huixin;Xu, Ye;Liu, Dadan;Chen, Liang;Zhang, Hongfu;Zhang, Shunfen;Lv, Huiyuan;Ma, Qiugang;Zhou, Miao
关键词：baicalin;
E. coli ; intestinal inflammation;Lactobacillus amylovorus ; macrophages polarization; TLR4 -
Bacterial communities driving cabbage yield increases and pathogenic risks reduces following wastewater irrigation: Effects of nitrification inhibitors on different soil-vegetable systems
作者：Zhang, Manyun;Zhou, Minzhe;Wang, Hua;Ma, Bin;Zhou, Tangrong;Wang, Yan;Huang, Zhenrong;Tang, Wenhui;Chen, Falin;Zhao, Xinlin;Zhang, Manyun;Bai, Shahla Hosseini;Zhao, Benliang
关键词：Nitrification inhibitors; Rice-fish symbiosis wastewater; Potential pathogenicity; Bacterial community
-
Digital Economy, Rural E-Commerce Development, and Farmers' Employment Quality
作者：Wang, Yan;Wu, Yongjie;Wang, Yan
关键词：digital economy; rural e-commerce development; farmers' employment quality
-
Genetic analysis and identification of major locus and candidate genes linked to thousand-seed weight in flax (Linum usitatissimum)
作者：Qi, Yanni;Wang, Limin;Li, Wenjuan;Dang, Zhao;Zhao, Wei;Wang, Ping;Xie, Yaping;Xu, Chenmeng;Wang, Yan;Zhang, Jianping;Wang, Wei
关键词：Flax; TSW; BSA-seq; Fine mapping; qRT-PCR
-
Remodelling autoactive NLRs for broad-spectrum immunity in plants
作者：Wang, Junzhu;Chen, Tianyuan;Zhang, Zhendong;Song, Mengjie;Shen, Tianxin;Wang, Xin;Zheng, Xiyin;Wang, Yan;Song, Ke;Qi, Tiancong;Liu, Yule;Wang, Junzhu;Chen, Tianyuan;Zhang, Zhendong;Song, Mengjie;Shen, Tianxin;Wang, Xin;Zheng, Xiyin;Wang, Yan;Song, Ke;Qi, Tiancong;Liu, Yule;Wang, Junzhu;Chen, Tianyuan;Zhang, Zhendong;Song, Mengjie;Shen, Tianxin;Wang, Xin;Zheng, Xiyin;Wang, Yan;Song, Ke;Qi, Tiancong;Liu, Yule;Ge, Xiaoyang;Li, Fuguang;Xu, Kai;Hong, Yiguo;Hong, Yiguo;Hong, Yiguo
关键词：
-
Cysteine-Mediated Root Growth Promotion in Strawberry (Fragaria x ananassa) Induced by TgSWO-Overexpressing Trichoderma
作者：Meng, Xiaohui;Zhang, Xu;Yang, Hongjun;Lu, Yilei;Xu, Ye;Yan, Zhiming;Wang, Yuanhua;Zhang, Xiong
关键词：
Trichoderma guizhouense ; TgSWO; cysteine; strawberry; root growth promotion -
The use of adeno-associated virus-based gene therapy to achieve long-term expression of recombinant neutralizing antibody against ricin
作者：Yu, Kaikai;Sun, Chengbiao;Dong, Mingxin;Wang, Yan;Liu, Wensen;Zhao, Na;Xu, Na;Song, Suli;Wang, Yan
关键词：Ricin; Adeno-associated virus; Passive immunity; Nucleic acid antibody; Neutralizing mechanism
