The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitro
文献类型： 外文期刊
作者： Yang, Qingran 1 ; Guo, Haoran 2 ; Li, Huili 2 ; Li, Zhaoxue 2 ; Ni, Fushun 2 ; Wen, Zhongmei 3 ; Liu, Kai 4 ; Kong, Huihui 5 ; Wei, Wei 2 ;
作者机构： 1.Jilin Univ, Hosp 1, Childrens Med Ctr, Dept Respirat, Changchun, Jilin, Peoples R China
2.Jilin Univ, Hosp 1, Inst Virol & AIDS Res, Changchun, Jilin, Peoples R China
3.Jilin Univ, Hosp 1, Ctr Pathogen Biol & Infect Dis, Dept Resp Med, Changchun, Jilin, Peoples R China
4.Tsinghua Univ, Dept Chem, Beijing, Peoples R China
5.Univ Wisconsin Madison, Influenza Res Inst, Sch Vet Med, Dept Pathobiol Sci, Madison, WI USA
6.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China
7.Jilin Univ, Hosp 1, Inst Translat Med, Canc Ctr,Key Lab Organ Regenerat & Transplantat Mi, Changchun, Jilin, Peoples R China
期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）
ISSN：
年卷期： 2025 年 16 卷 1 期
页码：
收录情况： SCI
摘要： Respiratory viruses pose an ongoing threat to human health with excessive cytokine secretion contributing to severe illness and mortality. However, the relationship between cytokine secretion and viral infection remains poorly understood. Here we elucidate the role of CXCL8 as an early response gene to EV-D68 infection. Silencing CXCL8 or its receptors, CXCR1/2, impedes EV-D68 replication in vitro. Upon recognition of CXCL8 by CXCR1/2, the MAPK pathway is activated, facilitating the translocation of nuclear hnRNP-K to the cytoplasm. This translocation increases the recognition of viral RNA by hnRNP-K in the cytoplasm, promoting the function of the 5 ' untranslated region in the viral genome. Moreover, our investigations also reveal the importance of the CXCL8 signaling pathway in the replication of both influenza virus and rhinovirus. In summary, our findings hint that these viruses exploit the CXCL8/MAPK/hnRNP-K axis to enhance viral replication in respiratory cells in vitro.
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