A Circular RNA Generated from Nebulin (NEB) Gene Splicing Promotes Skeletal Muscle Myogenesis in Cattle as Detected by a Multi-Omics Approach
文献类型： 外文期刊
作者： Huang, Kongwei 1 ; Li, Zhipeng 1 ; Zhong, Dandan 1 ; Yang, Yufeng 1 ; Yan, Xiuying 1 ; Feng, Tong 1 ; Wang, Xiaobo 1 ; Zhang, Liyin 1 ; Shen, Xinyue 1 ; Chen, Mengjie 1 ; Luo, Xier 2 ; Cui, Kuiqing 2 ; Huang, Jieping 1 ; Rehman, Saif Ur 1 ; Jiang, Yu 4 ; Shi, Deshun 1 ; Pauciullo, Alfredo 5 ; Tang, Xiangfang 6 ; Liu, Qingyou 1 ; Li, Hui 1 ;
作者机构： 1.Guangxi Univ, Coll Anim Sci & Technol, State Key Lab Conservat & Utilizat Subtrop Agro Bi, Guangxi Key Lab Anim Breeding Dis Control & Preven, Nanning 530005, Peoples R China
2.Foshan Univ, Sch Life Sci & Engn, Guangdong Prov Key Lab Anim Mol Design & Precise, Foshan 528225, Peoples R China
3.South China Univ Technol, Sch Biol & Biol Engn, Guangzhou 510641, Peoples R China
4.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China
5.Univ Torino, Dept Agr Forest & Food Sci, I-10095 Grugliasco, TO, Italy
6.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr & Feeding, Beijing 100193, Peoples R China
关键词： Cattle; circNEB; myogenesis; Ribo-seq; SCF complex; skeletal muscle
期刊名称：ADVANCED SCIENCE （ 影响因子：15.1； 五年影响因子：16.7 ）
ISSN：
年卷期： 2023 年
页码：
收录情况： SCI
摘要： Cattle and the draught force provided by its skeletal muscle have been integral to agro-ecosystems of agricultural civilization for millennia. However, relatively little is known about the cattle muscle functional genomics (including protein coding genes, non-coding RNA, etc.). Circular RNAs (circRNAs), as a new class of non-coding RNAs, can be effectively translated into detectable peptides, which enlightened us on the importance of circRNAs in cattle muscle physiology function. Here, RNA-seq, Ribosome profiling (Ribo-seq), and peptidome data are integrated from cattle skeletal muscle, and detected five encoded peptides from circRNAs. It is further identified and functionally characterize a 907-amino acids muscle-specific peptide that is named circNEB-peptide because derived by the splicing of Nebulin (NEB) gene. This peptide localizes to the nucleus and cytoplasm and directly interacts with SKP1 and TPM1, key factors regulating physiological activities of myoblasts, via ubiquitination and myoblast fusion, respectively. The circNEB-peptide is found to promote myoblasts proliferation and differentiation in vitro, and induce muscle regeneration in vivo. These findings suggest circNEB-peptide is an important regulator of skeletal muscle regeneration and underscore the possibility that more encoding polypeptides derived by RNAs currently annotated as non-coding exist.
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