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Identification of Major Metabolites of Salbutamol in Swine Urine and Plasma Using Ultra-High Performance Liquid Chromatography-Electrospray Time of Flight Mass Spectrometry

文献类型: 外文期刊

作者: Gu Xu 1 ; Liu Yi-Ming 1 ; Yao Ting 1 ; Shi Hua-Le 1 ; Li Jun 1 ; Zhao Zhen 1 ; Qin Yu-Chang 2 ;

作者机构: 1.Chinese Acad Agr Sci, Feed Res Inst, Beijing 100081, Peoples R China

2.Minist MOA, Food & Nutr Dev Inst, Beijing 100081, Peoples R China

关键词: Salbutamol;Ultra-high performance liquid chromatography-electrospray time of flight mass spectrometry;Metabolites

期刊名称:CHINESE JOURNAL OF ANALYTICAL CHEMISTRY ( 影响因子:1.134; 五年影响因子:0.909 )

ISSN: 0253-3820

年卷期: 2014 年 42 卷 11 期

页码:

收录情况: SCI

摘要: The excretion of urinary and plasmic metabolites of salbutamol was studied using ultra performance liquid chromatography electrospray ionization quadrupole time-of-flight tandem mass spectrometry, after a single intragastric gavaged dose administration with salbutamol. The software of Agilent Mass Hunter Metabolite ID was employed to find and identify the chemical structure of metabolites of salbutamol. Five metabolites from salbutamol were identified. The metabolites identified in swine urine included glucuronide conjugate salbutamol, N-oxide-salbutamol, hydroxyl-salbutamol, methoxyl-salbutamol and dehydrated hydroxyl-salbutamol. Whereas, only the parent drugs, glucuronide conjugate salbutamol and N-oxide salbutamol were observed in plasma.

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