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Mechanism of polyphenol-pea starch complexes on reducing fat accumulation in Caenorhabditis elegans

文献类型： 外文期刊

作者： Luo, Dan 1 ; Wang, Wei 2 ; Jin, Manqin 1 ; Zhang, Xuemei 1 ; Fan, Jiaxing 1 ; Yang, Yingkang 3 ; Zhai, Chen 3 ; Rao, Huan 4 ; Xue, Wentong 1 ;

作者机构： 1.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China

2.Shijiazhuang Acad Agr & Forestry Sci, Shijiazhuang 050041, Hebei, Peoples R China

3.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

4.Hebei Univ Sci & Technol, Coll Food Sci & Biol, Shijiazhuang 050018, Hebei, Peoples R China

关键词： Pea starch; Caenorhabditis elegans; Lipid-lowering effect; Polyphenol-starch complexes; MDT-15; ROS

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.0； 五年影响因子：8.5 ）

ISSN： 0963-9969

年卷期： 2025 年 209 卷

页码：

收录情况： SCI

摘要： Obesity is characterized by lipid metabolism disorders and excessive fat accumulation, imposing a significant burden on individuals and society. Polyphenol-pea starch (PS) complexes have shown considerable potential in alleviating fat accumulation, yet the mechanisms underlying these effects remain unclear. This study investigated the effects and underlying mechanisms of gallic acid-PS (GAL-PS), ferulic acid-PS (FER-PS), quercetin-PS (QUEPS), and tannic acid-PS (TAN-PS) complexes at a dosage of 1 mg/mL in reducing fat accumulation in Caenorhabditis elegans. The results revealed that GAL-PS, FER-PS, QUE-PS, and TAN-PS complexes significantly reduced triglyceride content in high-fat C. elegans by 38.61 %, 10.81 %, 18.60 %, and 25.78 %, respectively. Additionally, these polyphenol-PS complexes reduced both the size and number of lipid droplets in ZXW618, which are mutant expressing the lipid droplet membrane protein dehydrogenase-3 linked to GFP, and increased the proportions of unsaturated fatty acids and antioxidant activities in high-fat worms. Mechanistically, polyphenol-PS complexes regulated multiple lipid metabolism pathways via MDT-15/SBP-1 and MDT-15/NHR-49 signaling pathways, which include fat-5, fat-6, and fat-7, pod-2, fasn-1, and elo-2 genes modulated fat synthesis, acs-2, aak-2, tub-1, and skn-1 genes participated in fat consumption, and tub-1, and vit-2 regulated fat storage. Our findings provide a novel perspective and theoretical foundation for the reducing fat accumulation by polyphenol starch-based food biomacromolecules and their potential applications in starchy foods.

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