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Duck Tembusu virus induced mitophagy in vacuolate spermatogenic cells is mediated by PINK1-Parkin pathway

文献类型： 外文期刊

作者： Huang, Yufei 1 ; Yan, Xiaoman 1 ; Chu, Xiaoya 4 ; Shi, Yonghong 5 ; Xiang, Jacob 6 ; Yang, Sheng 1 ;

作者机构： 1.Yangzhou Univ, Inst Comparat Med, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China

2.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

3.Yangzhou Univ, Guangling Coll, Yangzhou 225009, Jiangsu, Peoples R China

4.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Jiangsu, Peoples R China

5.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

6.Foothills Med Ctr, 140329St NW, Calgary, AB T2N 2T9, Canada

关键词： Duck Tembusu virus; Testis; Autophagy; Permatogenic cells; Mitochondria

期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）

ISSN： 0032-5791

年卷期： 2025 年 104 卷 2 期

页码：

收录情况： SCI

摘要： As a significant emerging and re-emerging pathogen in China, the widely spread of Duck Tembusu virus (DTMUV) caused enormous economic losses to poultry industry. On account of DTMUV diseases' main symptoms on haemorrhagic oophoritis, intensive attentions were focused on female reproductive organ. Nevertheless, the DTMUV infection of sperm and testis manifested that testis was an important vector for vertical transmission of DTMUV. In the present study, histopathology, immunofluorescence and transmission electron microscopy (TEM) analysis of DTMUV-infected duck testis revealed that DTMUV infection induced seminiferous epithelium injury via spermatogenic cells vacuolization. After DTMUV infection, the expression of autophagy-related genes and proteins in testis were significantly up-regulated. Further TEM analysis discovered that different stages of autophagic and mitophagy structures were visible in cytoplasm of spermatogenic cells after DTMUV infection. And more notably, the testicular protein expression of PINK1 and Parkin were significantly increased after DTMUV infection. In summary, our study discovered that, after DTMUV infection, PINK1-Parkin pathway mediated mitophagy were activated and then induced spermatogenic cells vacuolization.

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