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FvMbp1-Swi6 complex regulates vegetative growth, stress tolerance, and virulence in Fusarium verticillioides

文献类型： 外文期刊

作者： Huang, Yufei 1 ; Chen, Jinfeng 1 ; Xia, Haoxue 2 ; Gao, Zenggui 1 ; Gu, Qin 3 ; Liu, Wende 2 ; Tang, Guangfei 2 ;

作者机构： 1.Shenyang Agr Univ, Coll Plant Protect, Shenyang 110866, Peoples R China

2.Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing 100193, Peoples R China

3.Nanjing Agr Univ, Key Lab Monitoring & Management Crop Dis & Pest In, Coll Plant Protect, Dept Plant Pathol,Minist Educ, Nanjing, Peoples R China

关键词： Fusarium verticillioides; FvMbp1; FvSwi6; Vegetative growth; Virulence

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：12.2； 五年影响因子：11.9 ）

ISSN： 0304-3894

年卷期： 2024 年 473 卷

页码：

收录情况： SCI

摘要： The mycotoxigenic fungus Fusarium verticillioides is a common pathogen of grain and medicine that contaminates the host with fumonisin B1 (FB1) mycotoxin, poses serious threats to human and animal health. Therefore, it is crucial to unravel the regulatory mechanisms of growth, and pathogenicity of F. verticillioides. Mbp1 is a component of the MluI cell cycle box binding factor complex and acts as an APSES-type transcription factor that regulates cell cycle progression. However, no information is available regarding its role in F. verticillioides. In this study, we demonstrate that FvMbp1 interacts with FvSwi6 that acts as the cell cycle transcription factor, to form the heteromeric transcription factor complexes in F. verticillioides. Our results show that Delta FvMbp1 and Delta FvSwi6 both cause a severe reduction of vegetative growth, conidiation, and increase tolerance to diverse environmental stresses. Moreover, Delta FvMbp1 and Delta FvSwi6 dramatically decrease the virulence of the pathogen on the stalk and ear of maize. Transcriptome profiling show that FvMbp1-Swi6 complex co-regulates the expression of genes associated with multiple stress responses. These results indicate the functional importance of the FvMbp1-Swi6 complex in the filamentous fungi F. verticillioides and reveal a potential target for the effective prevention and control of Fusarium diseases.

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