您好，欢迎访问中国农业科学院 机构知识库！

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Cellular Evidence for Telocytes Mediating Electroacupuncture to Ameliorate Obesity in Mice

文献类型： 外文期刊

作者： Mei, Lu 1 ; Zhu, Qianmei 1 ; Bai, Xuebing 1 ; Zhang, Yingxin 1 ; Huang, Haixiang 1 ; Yang, Min 1 ; Shi, Yonghong 1 ; Liang, Chunhua 1 ; Zhang, Zhenwei 1 ; Chen, Qiusheng 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Jiangsu, Peoples R China

2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Ziyue Rd, Shanghai 200241, Peoples R China

关键词： electroacupuncture; meridian; mice; obesity; Telocytes

期刊名称：MICROSCOPY AND MICROANALYSIS （ 影响因子：2.8； 五年影响因子：3.3 ）

ISSN： 1431-9276

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Electroacupuncture has been generally applied to target obesity, the principle of which is based on the meridian in traditional Chinese medicine. Although Telocytes (TCs) have been reported as the potential essence of meridians, their specific role in the electroacupuncture treatment of obesity remains unclear. Thus, we investigated the cellular evidence for TC-mediated electroacupuncture to alleviate obesity. Mice were divided into three groups as follows: electroacupuncture group (EA), control group (CG), and normal group (NG). The present study showed that the weight of perirenal white adipose tissue (rWAT), the serum level of total cholesterol, and the low-density lipoprotein cholesterol were all significantly decreased after electroacupuncture. Ultrastructurally, the prolongations (telopodes, Tps) of TCs were in direct contact with adipocytes, and lipid droplets were distributed on the surface of Tps. The proportions of double-positive fluorescent areas of TCs (CD34 and PDGFR alpha) were significantly elevated with concomitant elongated Tps in EA mice, as compared to those in CG mice. The expression of Cx43 and CD63 (gap junction and exosome markers) was significantly enhanced. These characteristics facilitated the transmission of electroacupuncture stimulation from skin to rWAT. We conclude that electroacupuncture relieved obesity by activating TCs morphologically, upregulating the gap junctions between TCs, and increasing the exosomes around TCs.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台