文献类型： 外文期刊
作者： Yang, Min 1 ; Yang, Tong 1 ; Mei, Lu 1 ; Zhang, Yingxing 1 ; Liang, Chunhua 1 ; Bai, Xuebing 1 ; Zhang, Zhenwei 1 ; Shi, Yonghong 2 ; Chen, Qiusheng 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai, Peoples R China
3.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, 1 Weigang, Nanjing 210095, Peoples R China
关键词： cardiac telocytes; berberine; Ca2+; CX43
期刊名称：PLANTA MEDICA （ 影响因子：2.7； 五年影响因子：3.2 ）
ISSN： 0032-0943
年卷期： 2023 年
页码：
收录情况： SCI
摘要： A brand-new class of interstitial cells, called telocytes, has been detected in the heart. Telocytes can connect and transmit signals to almost all cardiomyocytes; this is highly interrelated with the occurrence and development of heart diseases. Modern studies have shown that berberine has a therapeutic effect on cardiovascular health. However, berberine's mechanism of action on the cardiovascular system through cardiac telocytes is unclear. Interestingly, 5 mu m of berberine remarkably decreased the concentration of intracellular calcium and membrane depolarization in cultured telocytes, upregulated the expression of CX43 and beta-catenin, and downregulated the expressions of TRPV4 and TRPV1. Here, telocytes were identified in the vascular adventitia and intima, endocardium, myocardium, adventitia, and heart valves. Moreover, telocytes were broadly dispersed around cardiac vessels and interacted directly through gap junctions and indirectly through extracellular vesicles. Together, cardiac telocytes interact with berberine and then deliver drug information to the heart. Telocytes may be an essential cellular target for drug therapy of the cardiovascular system.
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