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Green synthesis of PVA-LS-MXene composite conductive hydrogel for high-performance skin wound dressings

文献类型： 外文期刊

作者： Lei, Siqi 1 ; Qin, Xiaoli 6 ; Shen, Shuhui 1 ; Ma, Xiaohong 1 ; Yang, Cunkuan 1 ; Mai, Xiaoxue 2 ; Cao, Xiaoan 5 ; Liu, Zhijie 5 ; Xie, Weibo 1 ; Yang, Shengrong 3 ; Wang, Jinqing 3 ;

作者机构： 1.Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China

2.Lanzhou Univ, Hosp 2, Lanzhou 730030, Peoples R China

3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China

4.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

5.Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Lanzhou Vet Res Inst, Lanzhou 730046, Peoples R China

6.Longgang Cent Hosp, Dept Stomatol, Shenzhen 518116, Guangdong, Peoples R China

关键词： MXene; Wound dressing; Bacterial infection; Hydrogel

期刊名称：JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS （ 影响因子：3.5； 五年影响因子：3.7 ）

ISSN： 1751-6161

年卷期： 2025 年 170 卷

页码：

收录情况： SCI

摘要： Polyvinyl alcohol (PVA)-based hydrogels have been demonstrated to possess excellent biocompatibility and hydrophilicity. Nevertheless, their restricted mechanical resilience and antimicrobial properties have substantially constrained their utility in advanced wound care applications. To address these critical limitations, we constructed a conductive composite hydrogel as a potential wound dressing through strategic incorporation of lignin (LS) and MXene nanosheets into a PVA matrix. This ternary system establishes robust intermolecular networks via non-covalent interactions, effectively overcoming the historical challenges of inadequate mechanical performance and insufficient antimicrobial efficacy in conventional hydrogel dressings. The composite hydrogel displays high tensile strength (up to 340.8 kPa), elongation at break of up to 239.9 %, and compression modulus of more than 0.41 MPa. Meanwhile, the composite hydrogel exhibits excellent antimicrobial activity and biocompatibility, which helps to minimize wound infections and promote wound healing. Furthermore, the PLM composite hydrogel markedly accelerated wound healing in a mouse wound model. In this work, an environmentally benign PLM composite membrane demonstrated multifunctional therapeutic potential through synergistic integration of antioxidant, anti-inflammatory, and electroconductive properties, offering an efficacious multimodal therapy for infected and damaged skin.

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