文献类型： 外文期刊
作者： Cao, Xiaoan 1 ; Liu, Ping 1 ; Wu, Jinyan 1 ; Liu, Zhijie 1 ; Zhang, Yuling 2 ; Yin, Cai 2 ; Ying, Lan 3 ; Ma, Jinrui 1 ; He, Jijun 1 ; Shang, Youjun 1 ; Du, Rui 4 ; Liu, Zhiguo 5 ; Li, Zhenjun 5 ;
作者机构： 1.Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Lanzhou Vet Res Inst, Lanzhou 730046, Peoples R China
2.Ningxia Anim Dis Prevent & Control Ctr, Yinchuan 750000, Peoples R China
3.Qinghai Anim Dis Prevent & Control Ctr, Xining 810000, Peoples R China
4.Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China
5.Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing 102206, Peoples R China
关键词：
期刊名称：BMC MICROBIOLOGY （ 影响因子：4.2； 五年影响因子：4.8 ）
ISSN： 1471-2180
年卷期： 2025 年 25 卷 1 期
页码：
收录情况： SCI
摘要： Brucellosis poses a severe threat to public health in Northwest China; however, the genome phylogeny and transmission pattern of Brucella melitensis from sheep and yaks in this region remain unclear. In this study, bacteriology, conventional biototyping, and whole-genome single-nucleotide polymorphism (WGS-SNP) were applied to depict the phylogenetic profiles of strains from Northwest China. A total of 46 Brucella strains were identified as B. melitensis bv. 3, which was isolated from at least three animal (livestock and wildlife) hosts, implying that B. melitensis infection is prevalent in the Northwest and suggesting that host diversity provides an optimal niche for the spread and maintenance of B. melitensis in this region. WGS-SNP analysis divided the 46 B. melitensis strains into four clades (C-I-IV) that harbored eight SNP genotypes (STs), implying that at least four lineages are prevalent in the Northwest. Global WGS-SNP phylogenetic analysis of strains revealed that all Northwest strains belong to genotype II. Strains from different clades presented high genetic similarity with strains previously collected from the Northwest. This study provides robust evidence supporting the notion that multiple similar B. melitensis lineages are persistently prevalent in human populations and animals in the Northwest. The economic development of animal husbandry has accelerated the cross-regional flow of livestock and livestock products, driving the spread and reach of the disease. Therefore, tailoring a targeted control strategy is necessary to counter the current serious epidemic trend.
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