文献类型： 外文期刊
作者： Zhu, Guoliang 1 ; Xi, Fei 1 ; Zeng, Wuxia 1 ; Zhao, Yifei 1 ; Cao, Weijun 1 ; Liu, Chen 1 ; Yang, Fan 1 ; Ru, Yi 1 ; Xiao, Shuqi 1 ; Zhang, Shilei 1 ; Liu, Huanan 1 ; Tian, Hong 1 ; Yang, Fayu 1 ; Lu, Biao 1 ; Sun, Shukai 1 ; Song, Haiyang 1 ; Sun, Bozhang 1 ; Zhao, Xiaoyi 1 ; Tang, Lijie 3 ; Li, Kangli 1 ; He, Jijun 1 ; Guo, Jianhong 1 ; Zhu, Yun 4 ; Zhu, Zixiang 1 ; Sun, Fei 4 ; Zheng, Haixue 1 ;
作者机构： 1.Lanzhou Univ, Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Coll Vet Med,Lanzhou Vet Res Inst, Lanzhou, Peoples R China
2.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, African Swine Fever Reg Lab China, Lanzhou, Peoples R China
3.Northeast Agr Univ, Coll Vet Med, Dept Prevent Vet Med, Harbin, Heilongjiang, Peoples R China
4.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromolecules, Natl Lab Biomacromolecules, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Sch Life Sci, Beijing, Peoples R China
6.Gansu Prov Res Ctr Basic Disciplines Pathogen Biol, Lanzhou, Peoples R China
期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）
ISSN：
年卷期： 2025 年 16 卷 1 期
页码：
收录情况： SCI
摘要： African swine fever virus is highly contagious and causes a fatal infectious disease in pigs, resulting in a significant global impact on pork supply. The African swine fever virus RNA polymerase serves as a crucial multifunctional protein complex responsible for genome transcription and regulation. Therefore, it is essential to investigate its structural and functional characteristics for the prevention and control of African swine fever. Here, we determine the structures of endogenous African swine fever virus RNA polymerase in both nucleic acid-free and elongation states. The African swine fever virus RNA polymerase shares similarities with the core of typical RNA polymerases, but possesses a distinct subunit M1249L. Notably, the dynamic binding mode of M1249L with RNA polymerase, along with the C-terminal tail insertion of M1249L in the active center of DNA-RNA scaffold binding, suggests the potential of M1249L to regulate RNA polymerase activity within cells. These results are important for understanding the transcription cycle of the African swine fever virus and for developing antiviral strategies.
- 相关文献
作者其他论文 更多>>
-
Perillaldehyde controls citrus green mold by inhibiting the ribosome biogenesis of Penicillium digitatum and improving citrus disease resistance
作者：Liu, Shuqi;Jiang, Yuxin;Yang, Fan;Wang, Yuqing;Lu, Yongqing;Lai, Weiqiang;Long, Chao-an;Sun, Jiancheng;Yang, Fan;Long, Chao-an;Long, Chao-an
关键词：Perillaldehyde; Penicillium digitatum; Citrus; Green mold; ROS
-
Chromosome-level genome assembly of the sweet potato rot nematode Ditylenchus destructor
作者：Yang, Yiwei;Hong, Bo;Liu, Chen;Li, Yingmei;Chang, Qing;Feng, Ruirui;Fang, Yuchuan;Wang, Kui;Peng, Deliang;Peng, Huan
关键词：
-
Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy: tackling herpesvirus drug resistance
作者：Yang, Fayu;Wei, Nan;Cai, Shuo;Liu, Jing;Zhang, Hao;Shang, Lu;Wang, Mi;Liu, Yingchun;Zhang, Lifang;Fei, Chenzhong;Tong, Wu;Liu, Changlong;Tong, Guangzhi;Gu, Feng;Yang, Fayu;Wei, Nan;Cai, Shuo;Liu, Jing;Zhang, Hao;Shang, Lu;Wang, Mi;Liu, Yingchun;Zhang, Lifang;Fei, Chenzhong;Gu, Feng;Yang, Fayu;Lan, Qingping;Kuang, Ersheng;Zheng, Bo
关键词：herpesviruses; CRISPR; host-directed therapy; CLC-2; DIDS
-
Rapid adaptation of Bacillus thuringiensis to alkaline environments via the L-lactate metabolism pathway regulated by the CRP/FNR family regulator LtmR
作者：Peng, Qi;Qin, Jiaxin;Xu, Hong;Kao, Guiwei;Yang, Fan;Sun, Zhongqin;Zhang, Xin;Song, Fuping;Qin, Jiaxin;Sun, Zhongqin;Guo, Shuyuan;Peng, Qi;Slamti, Leyla
关键词：Bacillus thuringiensis; CRP/FNR family regulator; Alkaline adaptation
-
Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: enhanced immune response in piglets with CD154 molecules
作者：Li, Yuwan;Zeng, Weijun;Niu, Xinni;Yuan, Zhongmao;Li, Shurou;Lin, Jinru;Xie, Kaiyuan;Yi, Lin;Ding, Hongxing;Zhao, Mingqiu;Fan, Shuangqi;Chen, Jinding;Zhu, Zixiang
关键词：foot-and-mouth disease virus (FMDV); virus-like particle vaccine (VLP); CD154; T and B cell epitopes; ADDomer
-
The Effectiveness and Mechanisms of China's Grain Support Policies in Relation to Grain Yield-An Evaluation of a Wide Range of Policies
作者：Li, Tianjian;Yang, Fan;Zhang, Haotian;Lin, Qingning
关键词：grain policy; grain production; machine learning
-
HAX1 mediates SARS-CoV-2 spike-triggered unfolded protein response in host cells
作者：Zhu, Fang;Yang, Cong;Ren, Jin;Wang, Chengcheng;Hu, Ronggui;Sheng, Xiangpeng;Yang, Fan;Hu, Ronggui;Yang, Fan;Hu, Ronggui;Wang, Xuechen
关键词：ER stress; HAX1; SARS-CoV-2; Spike; unfolded protein response
