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Cannabis Derivatives as Ingredients of Functional Foods to Combat the COVID-19 Pandemic

文献类型： 外文期刊

作者： Qin, Xiaoli 1 ; Yang, Xiai 1 ; Deng, Yanchun 1 ; Guo, Litao 1 ; Li, Zhimin 1 ; Yang, Xiushi 1 ; Hou, Chunsheng 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Bast Fiber Crops, Changsha 410205, Peoples R China

2.Minist Agr & Rural Affairs, Key Lab Biol & Proc Bast Fiber Crops, Changsha 410205, Peoples R China

3.Changsha Technol Innovat Ctr Plant Derived Funct I, Changsha 410205, Peoples R China

关键词： cannabinoids; COVID-19/SARS-CoV-2; pharmacological and food applications; challenges and prospect

期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）

ISSN：

年卷期： 2025 年 14 卷 16 期

页码：

收录情况： SCI

摘要： Lower respiratory infections predominantly affect children under five and the elderly, with influenza viruses and respiratory syncytial viruses (including SARS-CoV-2) being the most common pathogens. The COVID-19 pandemic has posed significant global public health challenges. While vaccination remains crucial, its efficacy is limited, highlighting the need for complementary approaches to mitigate immune hyperactivation in severe COVID-19 cases. Medicinal plants like Cannabis sativa show therapeutic potential, with over 85% of SARS-CoV-2-infected patients in China receiving traditional herbal treatments. This review explores the antiviral applications of cannabis and its bioactive compounds, particularly against SARS-CoV-2, while evaluating their pharmacological and food industry potential. Cannabis contains over 100 cannabinoids, terpenes, flavonoids, and fatty acids. Cannabinoids may block viral entry, modulate immune responses (e.g., suppressing pro-inflammatory cytokines via CB2/PPAR gamma activation), and alleviate COVID-19-related psychological stress. There are several challenges with pharmacological and food applications of cannabinoids, including clinical validation of cannabinoids for COVID-19 treatment and optimizing cannabinoid solubility/bioavailability for functional foods. However, rising demand for health-focused products presents market opportunities. Genetic engineering to enhance cannabinoid yields and integrated pharmacological studies are needed to unlock cannabis's full potential in drug discovery and nutraceuticals. Cannabis-derived compounds hold promise for antiviral therapies and functional ingredients, though further research is essential to ensure safety and efficacy.

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