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Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

文献类型： 外文期刊

作者： Wang, Wei 1 ; Li, Wangchang 3 ; Liu, Weiwei 3 ; Wang, Zishuai 3 ; Xie, Bingkun 6 ; Yang, Xiaogan 4 ; Tang, Zhonglin 1 ;

作者机构： 1.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China

2.Huazhong Agr Univ, Key Lab Swine Genet Breeding, Minist Agr & Rural Affairs, Wuhan 430070, Peoples R China

3.Chinese Acad Agr Sci, Kunpeng Inst Modern Agr Foshan, Agr Genom Inst, Foshan 528226, Peoples R China

4.Guangxi Univ, Coll Anim Sci & Technol, Guangxi Key Lab Anim Breeding Dis Control & Preven, Nanning 530004, Peoples R China

5.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Key Lab Livestock & Poultry Multiomics MARA, Shenzhen Branch,Guangdong Lab Lingnan Modern Agr, Shenzhen 518124, Peoples R China

6.Guangxi Vocat Univ Agr, Anim Husb Res Inst, Nanning 530002, Peoples R China

关键词： obese- and lean-type pigs; multiple tissues; transcriptome; alternative splicing; skeletal muscle metabolism

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2024 年 15 卷 2 期

页码：

收录情况： SCI

摘要： Alternative splicing (AS) is a crucial mechanism in post-transcriptional regulation, contributing significantly to the diversity of the transcriptome and proteome. In this study, we performed a comprehensive AS profile in nine tissues obtained from Duroc (lean-type) and Luchuan (obese-type) pigs. Notably, 94,990 AS events from 14,393 genes were identified. Among these AS events, it was observed that 80% belonged to the skipped exon (SE) type. Functional enrichment analysis showed that genes with more than ten AS events were closely associated with tissue-specific functions. Additionally, the analysis of overlap between differentially alternative splicing genes (DSGs) and differentially expressed genes (DEGs) revealed the highest number of overlapped genes in the heart and skeletal muscle. The novelty of our study is that it identified and validated three genes (PYGM, MAPK11 and CAMK2B) in the glucagon signaling pathway, and their alternative splicing differences were highly significant across two pig breeds. In conclusion, our study offers novel insights into the molecular regulation of diverse tissue physiologies and the phenotypic differences between obese- and lean-type pigs, which are helpful for pig breeding.

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