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Boosting chemotherapy of bladder cancer cells by ferroptosis using intelligent magnetic targeting nanoparticles

文献类型： 外文期刊

作者： Cai, Xiaomeng 1 ; Ruan, Lifo 1 ; Wang, Dongqing 1 ; Zhang, Jiayu 1 ; Tang, Jiaruo 1 ; Guo, Chen 1 ; Dou, Rui 1 ; Zhou, Mengxue 1 ; Hu, Yi 4 ; Chen, Jun 1 ;

作者机构： 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

2.Univ Chinese Acad Sci UCAS, Chinese Acad Sci CAS, Beijing 100049, Peoples R China

3.Chinese Acad Agr Sci, Tea Res Inst, Key Lab Tea Biol & Resource Utilizat, Minist Agr, Hangzhou 310008, Peoples R China

4.Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China

关键词： Tumor of bladder; Superparamagnetic iron oxide nanoparticles; Immunotherapy; Macrophage; Lipid peroxidation; Reactive oxygen species

期刊名称：COLLOIDS AND SURFACES B-BIOINTERFACES （ 影响因子：5.8； 五年影响因子：5.4 ）

ISSN： 0927-7765

年卷期： 2024 年 234 卷

页码：

收录情况： SCI

摘要： A versatile nano-delivery platform was reported to enhance the tumor suppression effect of chemotherapy by augmenting tumor cells' ferroptosis. The platform consists of pomegranate-like magnetic nanoparticles (rPAE@SPIONs) fabricated by encapsulating superparamagnetic iron oxide nanoparticles (SPIONs) within a reduced poly(13-amino ester)s-PEG amphiphilic copolymer (rPAE). The resulting platform exhibits several func-tionalities. Firstly, it promotes the doxorubicin (DOX) release by leveraging the mild hyperthermia generated by NIR irradiation. Secondly, it triggers ferroptosis in tumor cells, inducing their demise. Thirdly, it induces po-larization of macrophages towards an anti-tumor M1 phenotype, contributing to ferroptosis of tumor cells and enhanced tumor cell suppression. This study effectively capitalizes on the versatility of SPIONs and offers a simple yet powerful strategy for developing a new nanosized ferroptosis-inducing agent, ultimately improving the inhibition of bladder cancer cells.

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